Associations of pentraxin 3 with cardiovascular disease and all-cause death: the Cardiovascular Health Study.
Associations of pentraxin 3 with cardiovascular disease and all-cause death: the Cardiovascular Health Study.
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DOI：
10.1161/atvbaha.108.178947
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发表时间：
2009-04
期刊：
影响因子：
--
通讯作者：
Psaty BM
中科院分区：
文献类型：
--
作者：
Jenny NS;Arnold AM;Kuller LH;Tracy RP;Psaty BM
我们研究了血管炎症标记物--五羟色胺3(PTX3)与心血管疾病(CVD)和全死因死亡的关系。1,583名未患心血管疾病的心血管健康研究参与者包括在内。非排他性病例组包括心绞痛(n=476)、心肌梗死(n=237)、卒中(n=310)、心血管疾病死亡(n=282)和全死因死亡(n=772)。参与者没有参加任何活动。亚临床脑血管病患者PTX3水平(1.9±1.89)ng/ml高于无亚临床脑血管病患者(1.71±1.88)ng/ml(P=0.001)。校正了年龄、性别和种族的Cox回归分析显示，PTX3的标准差增加(1.89 ng/ml)与心血管疾病死亡(危险比1.11；95%可信区间1.02-1.21)和全因死亡(1.08；1.02-1.15)相关。PTX3与心绞痛(1.09；0.98-1.20)、心肌梗死(0.96；0.81-1.12)或卒中(1.06；0.95-1.18)无关。将C反应蛋白(CRP)或心血管疾病危险因素添加到模型中对关联性没有显著影响。在这些老年人中，PTX3与心血管疾病和所有原因死亡有关，与CRP和心血管疾病危险因素无关。PTX3可能反映了与CRP不同的炎症方面，并可能提供对衰老和导致死亡的慢性衰老疾病中血管健康的洞察。
We examined associations of pentraxin 3 (PTX3), a vascular inflammation marker, with incident cardiovascular disease (CVD) and all cause death. 1,583 Cardiovascular Health Study participants free of prevalent CVD were included. Non-exclusive case groups were angina (n=476), myocardial infarction (MI; n=237), stroke (n=310), CVD death (n=282) and all cause death (n=772). 535 participants had no events. PTX3 levels were higher in those with subclinical CVD (1.90 ± 1.89 ng/ml) than those without (1.71 ± 1.88 ng/ml; p=0.001). Using Cox regression adjusted for age, sex and ethnicity, a standard deviation increase in PTX3 (1.89 ng/ml) was associated with CVD death (hazard ratio 1.11; 95% confidence interval 1.02–1.21) and all cause death (1.08; 1.02–1.15). PTX3 was not associated with angina (1.09; 0.98–1.20), MI (0.96; 0.81–1.12) or stroke (1.06; 0.95–1.18). Adding C-reactive protein (CRP) or CVD risk factors to the models had no significant effects on associations. In these older adults, PTX3 was associated with CVD and all cause death independent of CRP and CVD risk factors. PTX3 likely reflects different aspects of inflammation than CRP and may provide insight into vascular health in aging and chronic diseases of aging that lead to death.