Investigation of transcription factor AP-2beta genotype in women with premenstrual dysphoric disorder
Investigation of transcription factor AP-2beta genotype in women with premenstrual dysphoric disorder
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DOI：
10.1016/j.neulet.2004.11.068
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发表时间：
2005-03-22
影响因子：
2.5
通讯作者：
Eriksson, E
中科院分区：
文献类型：
--
作者：
Damberg, M;Westberg, L;Eriksson, E
它已多次表明，肾上腺素能系统参与经前焦虑障碍（PMDD）的神经病学。据报道，患有PMDD的女性与无PMDD的对照组相比，在与PMDD相关的生物标志物方面存在差异。来自家庭和双胞胎研究的证据表明，遗传因素对PMDD的病因学有贡献。人转录因子AP-2 β在神经嵴细胞谱系和神经外胚层细胞中的表达表明，该蛋白可能通过调节靶基因的表达对神经元的功能特性具有重要意义。在单胺能系统中，一些基因在调节区域中具有AP-2 β的结合位点，表明AP-2 β参与这些系统。编码AP-2 β的基因位于染色体6p 12-p21.1上，并且包括由位于第二内含子中的可变数目的[CAAA]重复组成的多态性区域。我们先前已经表明AP-2 β基因型与β-羟色胺能表型相关，脑干AP-2 β水平与大鼠额叶皮质5-羟色胺代谢呈正相关。本研究旨在探讨PMDD与转录因子AP-2 β基因型的关系。参与者包括176名PMDD女性和91名健康对照。采用聚合酶链反应进行基因分型。我们没有观察到PMDD受试者和对照组之间AP-2 β基因型频率的任何差异。我们的研究结果表明AP-2 β基因型不是PMDD的危险因素。据我们所知，这是第一个研究转录因子AP-2 β基因型在PMDD女性。因此，这些结果应被视为初步的，直到复制。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
It has repeatedly been shown that the serotonergic system is involved in the symptomatology of premenstrual dysphoric disorder (PMDD). Women with PMDD are reported to differ from symptom-free controls with regard to serotonin-related biological markers. Evidence from family and twin studies suggests a genetic contribution to the aetiology of PMDD. The expression of human transcription factor AP-2beta in neural crest cell lineages and neuroectodermal cells suggests that this protein may be of importance for functional characteristics of neurons by regulating the expression of target genes. Within the monoaminergic systems, several genes have binding sites for AP-2beta in regulatory regions, suggesting an involvement of AP-2beta in these systems. The gene encoding AP-2beta is located on chromosome 6pl2-p2l.1 and includes a polymorphic region consisting of a variable number of [CAAA] repeats located in the second intron. We have earlier shown that AP-2beta genotype is associated with serotonergic phenotypes and that brainstem levels of AP-2beta correlate positively to serotonin metabolism in rat frontal cortex. The aim of this study was to investigate the relationship between PMDD and transcription factor AP-2beta genotype. The participants included 176 women with PMDD and 91 healthy controls. Genotyping was performed by polymerase chain reactions. We did not observe any differences in AP-2beta genotype frequencies between PMDD subjects and controls. Our results suggest that AP-2beta genotype is not a risk factor for PMDD. To our knowledge, this is the first study investigating transcription factor AP-2beta genotype in women with PMDD. Hence, these results should be considered preliminary until replicated. (C) 2004 Elsevier Ireland Ltd. All rights reserved.