Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis.
Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis.
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DOI：
10.1111/jcmm.17184
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发表时间：
2022-03
影响因子：
5.3
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Xu Q;Liu Z;Cao Z;Shi Y;Yang N;Cao G;Zhang C;Sun R;Zhang C
落新妇苷是黄连的重要成分，对多种自身免疫性疾病具有显著的抗氧化和抗炎作用。我们之前已经报道过，在银屑病模型中，落新妇苷抑制了HaCaT角质形成细胞的增殖并促进了其分化。本研究旨在评价局部应用落新妇苷对咪喹莫特(imiquimod，imq)诱导的银屑病样小鼠模型的潜在治疗作用，并揭示其潜在的作用机制。低剂量的落新妇苷通过诱导小鼠表皮角质形成细胞分化，减轻ImQ诱导的银屑病样皮肤病变，其疗效甚至优于钙泊三醇。此外，用落新妇素治疗可以缓解炎症性皮肤病，其特点是减少皮肤皮损中产生IL-17的T细胞的积聚和牛皮癣特异性细胞因子的表达。此外，我们还发现，落新妇苷通过下调髓系分化因子88，抑制R837诱导的骨髓来源树突状细胞的成熟和激活，并减少促炎细胞因子的表达。我们的发现提供了令人信服的证据，表明低剂量的落新妇素可能通过干扰角质形成细胞的异常激活和分化以及产生IL-17的T细胞在皮损中的积聚来减轻银屑病。我们的结果有力地支持了落新妇苷在银屑病治疗中的临床前应用。
Astilbin, an essential component of Rhizoma smilacis glabrae, exerts significant antioxidant and anti‐inflammatory effects against various autoimmune diseases. We have previously reported that astilbin decreases proliferation and improves differentiation of HaCaT keratinocytes in a psoriatic model. The present study was designed to evaluate the potential therapeutic effects of topical administration of astilbin on an imiquimod (IMQ)‐induced psoriasis‐like murine model and to reveal their underlying mechanisms. Topical administration of astilbin at a lower dose alleviated IMQ‐induced psoriasis‐like skin lesions by inducing the differentiation of epidermal keratinocytes in mice, and the therapeutic effect was even better than that of calcipotriol. Moreover, the inflammatory skin disorder was relieved by astilbin treatment characterized by a reduction in both IL‐17‐producing T cell accumulation and psoriasis‐specific cytokine expression in skin lesions. Furthermore, we found that astilbin inhibited R837‐induced maturation and activation of bone marrow‐derived dendritic cells and decreased the expression of pro‐inflammatory cytokines by downregulating myeloid differentiation factor 88. Our findings provide the convincing evidence that lower doses of astilbin might attenuate psoriasis by interfering with the abnormal activation and differentiation of keratinocytes and accumulation of IL‐17‐producing T cells in skin lesions. Our results strongly support the pre‐clinical application of astilbin for psoriasis treatment.
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DOI：
10.1111/bjd.15610
发表时间：
2017-07
期刊：
The British journal of dermatology
影响因子：
--
作者：
Griffiths CEM;van der Walt JM;Ashcroft DM;Flohr C;Naldi L;Nijsten T;Augustin M
通讯作者：
Augustin M
影响因子：
10.3
作者：
Bell, R. R.;Dunstan, R. W.;Khan, N. K.
通讯作者：
Khan, N. K.
影响因子：
4.4
作者：
Ito, T;Amakawa, R;Fukuhara, S
通讯作者：
Fukuhara, S
Astilbin 通过 Jak3/Stat3 信号通路抑制 Th17 细胞分化并改善 BALB/c 小鼠中咪喹莫特诱导的银屑病样皮肤病变
影响因子：
5.6
作者：
Di, Ting-Ting;Ruan, Zhi-Tong;Li, Ping
通讯作者：
Li, Ping
影响因子：
15.3
作者：
Nestle, Frank O;Conrad, Curdin;Tun-Kyi, Adrian;Homey, Bernhard;Gombert, Michael;Boyman, Onur;Burg, Gunter;Liu, Yong-Jun;Gilliet, Michel
通讯作者：
Gilliet, Michel