Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development.
Genetic interactions with Rap1 and Ras1 reveal a second function for the fat facets deubiquitinating enzyme in Drosophila eye development.
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DOI：
10.1073/pnas.94.23.12515
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发表时间：
1997-11
影响因子：
11.1
通讯作者：
Qinghong Li;I. Hariharan;Fangli Chen;Yongzhao Huang;Janice A. Fischer
中科院分区：
文献类型：
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作者：
Qinghong Li;I. Hariharan;Fangli Chen;Yongzhao Huang;Janice A. Fischer
果蝇脂肪小平面基因编码一种去泛素酶，该酶调节在眼睛发育早期必不可少的细胞通讯途径，在小平面组装之前，将复眼每个小平面中的光感受器细胞数量限制在8个。脂肪小关节蛋白有助于在发育小关节外的细胞中产生信号，从而抑制特定小关节前体细胞的神经发育。这里描述了果蝇Rap1和Ras1基因的新的功能获得突变，这些突变与脂肪方面的突变在遗传上相互作用。对这些遗传交互作用的分析表明，脂肪方面在眼睛发育后期具有额外的功能，涉及Rap1和Ras1蛋白。此外，结果表明，小关节外的未分化细胞在眼睛发育的后期继续影响小关节的组装。
The Drosophila fat facets gene encodes a deubiquitinating enzyme that regulates a cell communication pathway essential very early in eye development, prior to facet assembly, to limit the number of photoreceptor cells in each facet of the compound eye to eight. The Fat facets protein facilitates the production of a signal in cells outside the developing facets that inhibits neural development of particular facet precursor cells. Novel gain-of-function mutations in the Drosophila Rap1 and Ras1 genes are described herein that interact genetically with fat facets mutations. Analysis of these genetic interactions reveals that Fat facets has an additional function later in eye development involving Rap1 and Ras1 proteins. Moreover, the results suggest that undifferentiated cells outside the facet continue to influence facet assembly later in eye development.