Retinal microaneurysms in leukaemia.
Retinal microaneurysms in leukaemia.
复制标题
白血病中的视网膜微动脉瘤。
DOI：
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发表时间：
1968
影响因子：
4.1
通讯作者：
S. Sigelman
中科院分区：
文献类型：
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作者：
J. Duke;C. Wilkinson;S. Sigelman
本报告的目的是描述死于白血病的患者视网膜微动脉瘤的存在。虽然这种类型的病变最常与糖尿病相关，但近年来，在临床上和/或组织学上，它已被描述为与多种明显不相关的实体相关。在少数情况下，病变出现与眼内局部条件有关。微动脉瘤经常在视网膜中央静脉或其分支形成血栓后被观察到（Loewenstein and Garrow, 1945; Ashton, 1951），它们也被描述与视网膜母细胞瘤（Ashton, 1951; Wolter, 1961）、Eales病（Wise, 1957）、Coats病（Lorentzen, 1959）、loa-loa （Toussaint and Danis, 1965）和脉络膜视网膜炎（Ashton, 1951; Wise, 1957）有关。它们也被观察到与多种全体性疾病有关：高血压（Friedenwald, 1950）、血红蛋白病（Edington和Sarkies, 1952； Goodman、von Sallmann和Holland， 1957）、蛋白异常贫血（Ashton、Kok和Foulds, 1963； Carr和Henkind， 1963）、紫绀疾病状态（Oliviera, 1966）、原发性和继发性红细胞增多症（Ashton等人，1963）、严重贫血(Friedenwald, 1950；Becker, Allen, Winter, Maengwyn-Davies, and Friedenwald, 1954)，无脉性疾病（Dowling and Smith, 1960），甚至作为衰老过程的一个组成部分（Kuwabara and Cogan, 1960）。Allen和Straatsma（1961）以及Mahneke和Videbaeh（1964）最近的两份临床病理报告强调了白血病患者视网膜病变的高发生率。常见的是静脉扩张、静脉曲张、白血病浸润、出血和渗出。乳头水肿和视网膜水肿较少见。这些最近的报道都没有将视网膜微动脉瘤作为白血病视网膜病变的特征。同样的，在最近关于视网膜血管病理学的文献回顾中，我们没有发现这些病变与白血病相关的报道。
THE purpose of this report is to describe the presence of microaneurysms in the retinae of patients who died with leukaemia. Although this type of lesion is most frequently observed in association with diabetes mellitis, it has, during recent years, been described clinically and/or histologically in association with a diverse variety of apparently unrelated entities. In a few instances the lesion appears in relation to conditions localized within the eye. Microaneurysms are frequently observed after thrombosis of the central retinal vein or one of its branches (Loewenstein and Garrow, 1945; Ashton, 1951), and they have also been described in association with retinoblastoma (Ashton, 1951; Wolter, 1961), Eales's disease (Wise, 1957), Coats's disease (Lorentzen, 1959), loa-loa (Toussaint and Danis, 1965), and chorioretinitis (Ashton, 1951; Wise, 1957). They have also been observed in association with a variety of systemic diseases: hypertension (Friedenwald, 1950), the haemoglobinopathies (Edington and Sarkies, 1952; Goodman, von Sallmann, and Holland, 1957), the dysproteinaemias (Ashton, Kok, and Foulds, 1963; Carr and Henkind, 1963), cyanotic disease states (Oliviera, 1966), primary and secondary polycythaemia (Ashton and others, 1963), severe anaemias (Friedenwald, 1950; Becker, Allen, Winter, Maengwyn-Davies, and Friedenwald, 1954), pulseless disease (Dowling and Smith, 1960), and even as a component of the process of ageing (Kuwabara and Cogan, 1960). Two recent clinico-pathological reports by Allen and Straatsma (1961) and by Mahneke and Videbaeh (1964) have stressed the high incidence of retinal lesions in patients with leukaemia. Commonly observed are dilated tortuous veins, leukaemic infiltrates, haemorrhages, and exudates. Papilloedema and retinal oedema are less frequently seen. Neither of these recent reports cited retinal microaneurysms as a feature of leukaemic retinopathy. Similarly, in a review of the recent literature concerning retinal vascular pathology, we were unable to find reports of these lesions in association with leukaemia.