Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR
Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR
复制标题
DOI：
10.1007/s11095-006-9089-z
复制
发表时间：
2006-11-01
影响因子：
3.7
通讯作者：
Yamamoto, Keiji
中科院分区：
文献类型：
--
作者：
Pongpeerapat, Adchara;Higashi, Kenjirou;Yamamoto, Keiji
目的：采用固体核磁共振技术研究了聚乙烯吡咯烷酮（PVP）相对分子质量对普罗布考/PVP/十二烷基硫酸钠（SDS）三元混合物（GM）固态分子间相互作用及纳米粒形成的影响（K12，K17，K30或K90）和SDS的重量比为1：3：1，并为15，30和60分钟的地面。固态相互作用进行了评价，使用粉末X射线衍射（PXRD）和固态交叉极化/魔角旋转（CP/MAS）C-13 NMR光谱。结果：固态C-13 CP/MAS NMR结果表明，在三元GM中，低分子量PVP与普罗布考和SDS的相互作用强于高分子量PVP。这一发现与使用低分子量PVP获得较小药物纳米颗粒的结果一致。普罗布考/PVP K12/SDS的SEM图像证实了GM中存在纳米颗粒（15-25 nm）。结论：可以使用固态C-13 NMR检测研磨诱导的药物、PVP和SDS之间的固态相互作用。普罗布考-PVP和PVP-SDS中的相互作用应同时发生，以产生普罗布考的纳米级颗粒。
Purpose: Effects of polyvinylpyrrolidone (PVP) molecular weight on the solid-state intermolecular interactions among probucol/PVP/sodium dodecyl sulfate (SDS) ternary ground mixtures (GM) and the formation of nanoparticles were investigated by solid-state NMR spectroscopy.Materials and Methods: Ternary GMs of probucol were prepared with PVP (K12, K17, K30 or K90) and SDS at a weight ratio of 1:3:1 and were ground for 15, 30 and 60 min. Solid-state interactions were evaluated using powder X-ray diffraction (PXRD) and solid-state cross polarization/magic angle spinning (CP/MAS) C-13 NMR spectroscopy. A high resolution scanning electron microscopy (SEM) was employed to observe nanoparticles of probucol in the GM.Results: The solid-state C-13 CP/MAS NMR results indicate that the low molecular weight PVP interacts with probucol and SDS more strongly than the high molecular weight PVP in the ternary GM. This finding was consistent with the result that smaller drug nanoparticles were obtained using low molecular weight of PVP. SEM images of probucol/PVP K12/SDS confirmed the presence of nanoparticles (15-25 nm) in the GM.Conclusions: Grinding-induced solid-state interactions among drug, PVP and SDS could be detected using solid state C-13 NMR. The interactions in both probucol-PVP and PVP-SDS should occur simultaneously to generate nanometer-sized particles of probucol.