Acoustic properties of atherosclerosis of human aorta obtained with high-frequency ultrasound
Acoustic properties of atherosclerosis of human aorta obtained with high-frequency ultrasound
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DOI：
10.1016/s0301-5629(98)00054-4
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发表时间：
1998-09-01
影响因子：
2.9
通讯作者：
Tanaka, M
中科院分区：
文献类型：
--
作者：
Saijo, Y;Sasaki, H;Tanaka, M
用扫描声学显微镜（SAM）测量主动脉组织成分的超声特性。12例尸检的主动脉经福尔马林固定、冷冻并切成10 μ m厚的切片，固定在载玻片上用于SAM研究。一个专门开发的SAM系统在100-200 MHz的频率范围内工作，并显示衰减和声速的二维（2-D）分布的彩色编码图像。通过比较光学和声学图像来确定衰减和声速测量的感兴趣区域（ROI）。正常内膜的衰减斜率平均值为0.61dB/mm/MHz，声速平均值为1568 m/s，钙化内膜为2.5dB/mm/MHz，声速平均值为1760 m/s，纤维化内膜为1.7dB/mm/MHz，声速平均值为1677 m/s，脂肪性内膜为0.34dB/mm/MHz，声速平均值为1526 m/s。声学显微镜为了解动脉粥样硬化的IVUS成像以及动脉粥样硬化的病理特征提供了基础数据，（C）1998年世界医学和生物学超声联合会。
The ultrasonic properties of the tissue elements in the aorta were measured using a scanning acoustic microscope (SAM), Twelve autopsied aortas were formalin-fixed, frozen and sectioned at 10 mu m thickness and mounted on glass slides for SAM investigation. A specially developed SAM system operating in the frequency range of 100-200 MHz was employed, and color-coded images of the two-dimensional (2-D) distributions of attenuation and sound speed were displayed. The region-of-interest (ROI) for attenuation and sound speed measurements was determined by comparison of optical and acoustic images. The average value of the slope of attenuation was 0.61 dB/mm/MHz and the sound speed was 1568 m/s in the normal intima; 2.5 dB/mm/MHz, 1760 m/s in the calcificated lesion; 1.7 dB/mm/MHz and 1677 m/s in the fibrosis; and 0.34 dB/mm/MHz, 1526 m/s in the fatty material, respectively. Acoustic microscopy provides the basic data for understanding the IVUS imaging of atherosclerosis, as well as on the pathological features of atherosclerosis, (C) 1998 World Federation for Ultrasound in Medicine & Biology.