Palladium-Catalyzed Electrochemical Allylic Alkylation between Alkyl and Allylic Halides in Aqueous Solution
Palladium-Catalyzed Electrochemical Allylic Alkylation between Alkyl and Allylic Halides in Aqueous Solution
复制标题
水溶液中钯催化烷基和烯丙基卤化物之间的电化学烯丙基烷基化
DOI：
10.1021/acs.orglett.7b00473
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发表时间：
2017-04-21
期刊：
影响因子：
5.2
通讯作者：
Huang, Jing-Mei
中科院分区：
文献类型：
--
作者：
Lai, Yin-Long;Huang, Jing-Mei
在空气条件下的水介质中，利用电化学技术开发了烷基和烯丙基卤化物直接交联的新途径。在Pd(OAc)(2)的催化下，锌介导的烯丙基烷基化反应在一系列卤化烷基（伯、仲、叔）和取代的烯丙基卤化物之间顺利进行。避免对底物中的酸性氢进行保护。
A new route for the direct cross-coupling of alkyl and allylic halides using electrochemical technique has been developed in aqueous media under air. Catalyzed by Pd(OAc)(2), the Zn-mediated allylic alkylations proceed smoothly between a full range of alkyl halides (primary, secondary, and tertiary) and substituted allylic halides. Protectiondeprotection of acidic hydrogen in the substrates is avoided.