The enigma of the major repeat sequence of Candida albicans
The enigma of the major repeat sequence of Candida albicans
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DOI：
10.2217/17460913.4.2.171
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发表时间：
2009-03-01
影响因子：
3.1
通讯作者：
Magee, Paul T.
中科院分区：
文献类型：
--
作者：
Chibana, Hiroji;Magee, Paul T.
在酵母白色念珠菌中发现的主要重复序列是一段重复 DNA，在这种机会性真菌病原体的单倍体基因组中出现了 9 次，在都柏林念珠菌基因组中出现的次数也可能相似。在白色念珠菌中，它占基因组的 1-2%。它的出现仅限于这两个物种。尽管其作为基因组特征的主要作用，但其功能、由于内部亚基重复而导致的大小扩展模式、以及其在整个基因组中的起源和分布机制尚不清楚，尽管它与染色体易位、染色体长度多态性和酵母菌丝二态性转变的调节有关。主要重复序列的多态性已被用于流行病学和分类学研究。这篇综述描述了它的序列、发生、在流行病学中的用途，并检查了它在染色体动力学中的作用的证据。
The major repeat sequence, discovered in the yeast Candida albicans, is a stretch of repeated DNA that occurs nine times in the haploid genome of this opportunistic fungal pathogen and probably a similar number of times in the genome of Candida dubliniensis. In C. albicans it constitutes 1-2% of the genome. Its occurrence is limited to those two species. Despite its major role as a genomic feature, its function, mode of expansion in size due to duplication of internal subunits, and its origin and mechanism of distribution throughout the genome are not understood, although it is associated with chromosome translocations, chromosome length polymorphisms and regulation of the yeast-hypha dimorphic transition. The polymorphism of the major repeat sequence has been exploited in epidemiology and taxonomic studies. This review describes its sequence, occurrence, use in epidemiology and examines the evidence for its role in chromosome dynamics.