Excitotoxic lesions of the bed nucleus of the stria terminalis (BNST) attenuate the effects of repeated stress on weight gain: evidence for the recruitment of BNST activity by repeated, but not acute, stress.
Excitotoxic lesions of the bed nucleus of the stria terminalis (BNST) attenuate the effects of repeated stress on weight gain: evidence for the recruitment of BNST activity by repeated, but not acute, stress.
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终纹床核 (BNST) 的兴奋性毒性损伤减弱了重复应激对体重增加的影响：重复而非急性应激可招募 BNST 活性的证据。
DOI：
10.1016/j.bbr.2011.11.010
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发表时间：
2012
影响因子：
2.7
通讯作者：
Hammack,SayamwongE
中科院分区：
文献类型：
--
作者：
Roman,CarolynW;Lezak,KimberlyR;Kocho-Schellenberg,Margaret;Garret,MarkA;Braas,Karen;May,Victor;Hammack,SayamwongE
暴露在反复的压力下会导致各种各样和广泛的行为后果，包括食物和水摄入量的减少以及随后体重增加的减少。许多报道表明，反复应激显著改变终纹床核(BNST)内神经元的神经化学、形态和生理学。在这里，我们研究了BNST在调节重复应激时观察到的体重增加减少中的作用。暴露于一周变量应激范式的大鼠在7天范式的过程中体重增加有所减少。在7天实验的早期，对前外侧BNST的一个包含卵圆形核的区域的兴奋毒性损伤没有任何影响，但显著地减弱了重复应激对最后一天体重增加的影响。这些数据表明，至少有两种机制调节了压力对体重增加的影响，当应激源暴露重复时，BNST被招募，从而恶化了应激源暴露的症状。
Exposure to repeated stress can lead to diverse and widespread behavioral consequences, including reduction in food and water intake and subsequent diminution in weight gain. Many reports have suggested that repeated stress substantially alters the neurochemistry, morphology and physiology of neurons within the bed nucleus of the stria terminalis (BNST). Here we investigate the role of the BNST in mediating the reduced weight gain observed during repeated stress. Rats exposed to a one-week variate stress paradigm exhibited a reduction in weight gain over the course of the 7-day paradigm. Excitotoxic lesions to a subregion of the anterolateral BNST containing the oval nucleus had no effects early in the 7-day paradigm, but significantly attenuated the effects of repeated stress on weight gain by the last day of stress. These data suggest that at least two mechanisms mediate the effects of stress on body weight gain, and that when stressor exposure becomes repeated, the BNST is recruited, worsening the symptoms of stressor exposure.