Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis.
Profiles of cognitive functioning in a population-based sample of centenarians using factor mixture analysis.
复制标题
使用因子混合物分析，认知功能的认知功能谱。
DOI：
10.1080/0361073x.2013.761869
复制
发表时间：
2013
影响因子：
1.8
通讯作者：
Georgia Centenarian
中科院分区：
文献类型：
--
作者：
Davey A;Dai T;Woodard JL;Miller LS;Gondo Y;Johnson MA;Hausman DB;Martin P;Green RC;Allen RH;Stabler SP;Poon LW;Georgia Centenarian
这项研究的目的是识别和描述百岁老人认知功能的潜在特征(簇)，以及他们内部认知测量的心理测量学特性。数据来自格鲁吉亚北部44个县的244名百岁老人的横断面人口样本(年龄98-108岁，男性15.8%，非裔美国人20.5%，社区居民38.0%)，这些人参加了佐治亚州百岁老人研究(2001-2009年)。测量内容包括简易智力状态检查(MMSE)、严重损害成套测验(SIB)、韦氏成人智力量表III、相似性分测验(WAIS)、手指敲击、行为障碍控制量表(BDS)、受控口头词语联想测验(COWAT)和Fuld物体记忆评估(FOME)。使用全球恶化评定量表(GDR)独立评估区分认知正常组和认知受损组的标准相关效度。相关协变量包括直接评估的日常生活基本和工具性活动(DAFS)的功能状态、种族、性别、教育程度、老年抑郁量表(GDS)以及视力和听力问题。结果表明，在这个百岁老人样本中，认知表现有两种截然不同的类别。大约三分之一的百岁老人在大多数指标上表现出明显较低的认知表现。GDR评分(敏感度67.7%，特异度82.4%)独立地很好地预测了群体成员(AUC=.83)。较低认知表现组的成员更有可能是年龄较大的非裔美国人、有更多抑郁症状、血浆叶酸较低、载脂蛋白Eε4等位基因携带者、设施居民以及在采访后两年内死亡的个人。在预计痴呆症患病率较高的人群中，可以通过为认知功能提供标准值的因素混合分析来区分潜在的亚型。本研究允许对这一年龄段的标准化认知表现进行估计。
The goal of the study was to identify and characterize latent profiles (clusters) of cognitive functioning in centenarians and the psychometric properties of cognitive measures within them. Data were collected from cross-sectional, population-based sample of 244 centenarians (aged 98-108, 15.8% men, 20.5% African-American, 38.0% community-dwelling) from 44 counties in Northern Georgia participating in the Georgia Centenarian Study (2001-2009). Measures included the Mini-Mental State Examination (MMSE), Severe Impairment Battery (SIB), Wechsler Adult Intelligence Scale-III, Similarities sub-test (WAIS), Finger Tapping, Behavioral Dyscontrol Scale (BDS), Controlled Oral Word Association Test (COWAT), and Fuld Object Memory Evaluation (FOME). The Global Deterioration Rating Scale (GDRS) was used to independently evaluate criterion-related validity for distinguishing cognitively normal and impaired groups. Relevant covariates included directly assessed functional status for basic and instrumental activities of daily living (DAFS), race, gender, educational attainment, Geriatric Depression Scale Short Form (GDS), and vision and hearing problems. Results suggest two distinct classes of cognitive performance in this centenarian sample. Approximately one-third of the centenarians show a pattern of markedly lower cognitive performance on most measures. Group membership is independently well-predicted (AUC=.83) by GDRS scores (sensitivity 67.7%, specificity 82.4%). Membership in the lower cognitive performance group was more likely for individuals who were older, African Americans, had more depressive symptoms, lower plasma folate, carriers of the APOE ε4 allele, facility residents, and individuals who died in the two years following interview. In a population expected to have high prevalence of dementia, latent subtypes can be distinguished via factor mixture analysis that provide normative values for cognitive functioning. The present study allows estimates for normative cognitive performance in this age group.