Analysis of cadmium accumulation in community adults and its correlation with low-grade albuminuria
Analysis of cadmium accumulation in community adults and its correlation with low-grade albuminuria
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DOI：
10.1016/j.scitotenv.2022.155210
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发表时间：
2022-04-27
影响因子：
9.8
通讯作者：
Yu, Chen
中科院分区：
文献类型：
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作者：
Feng, Xuefang;Zhou, Rong;Yu, Chen
目的：为探讨慢性非职业性镉暴露对中国城市居民肾损伤的影响，采用横断面研究方法，于2015年8月至2017年8月在上海招募了1000名参与者，收集了他们的社会人口学特征、终生职业和生活方式因素的数据。尿镉，尿白蛋白，尿肌酐，血清肌酐，尿素，尿酸水平进行了测试，683名参与者完成了这些measurements.Results：本研究人群的尿镉浓度中位数为0.77 μ g/g。尿镉浓度显着较高的女性，老年人，低体重指数人群。有148名显性蛋白尿的参与者的尿镉水平高于无显性蛋白尿的参与者（0.98 vs. 0.72 μ g/g; P < 0.001）。在无显性蛋白尿的受试者中，有134例受试者有轻度蛋白尿（13.84
Objective: To investigate the effects of chronic non-occupational exposure to cadmium(Cd) on renal injury in residents living in the urban areas of China.Methods: In this cross-sectional study, we recruited 1000 participants in Shanghai from August 2015 to August 2017 and collected data on their socio-demographic characteristics, lifetime occupation, and lifestyle factors. The urinary Cd, urinary albumin, urinary creatinine, serum creatinine, urea, and uric acid levels were tested, and 683 participants completed those measurements.Results: The median urinary Cd concentration of this study population was 0.77 mu g/g. The urinary Cd concentration was significantly higher in the female, older, and lower body mass index populations. There were 148 participants with dominant albuminuria who had higher urinary Cd levels than those without dominant albuminuria (0.98 vs. 0.72 mu g/g; P < 0.001). Among participants without dominant albuminuria, there were 134 participants with lowgrade albuminuria (13.84