Parcellation of the Human Orbitofrontal Cortex Based on Gray Matter Volume Covariance
Parcellation of the Human Orbitofrontal Cortex Based on Gray Matter Volume Covariance
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基于灰质体积协方差的人类眶额皮质分区
DOI：
10.1002/hbm.22645
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发表时间：
2015-02-01
影响因子：
4.8
通讯作者：
Yu, Chunshui
中科院分区：
文献类型：
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作者：
Liu, Huaigui;Qin, Wen;Yu, Chunshui
人类眶额皮质（OFC）是一个神秘的大脑区域，不能可靠地使用弥散和功能磁共振成像（fMRI），因为有信号丢失，这是由于成像技术的固有缺陷。我们假设，OFC可以可靠地根据来自无伪影结构图像的灰质体积（GMV）协方差模式划分为子区域。共有321名健康年轻受试者接受了高分辨率结构MRI检查。将OFC分成基于子区域的GMV协方差模式;然后比较每个OFC子区域的GMV协方差模式的性别和侧化差异。将人OFC分成前（OFCa）、中（OFCm）、后（OFCp）、中（OFCi）和外侧（OFCl）亚区。通过对男性和女性受试者的左侧OFC和双侧OFC进行相同的分析，验证了该分组方案。视觉观察和定量比较表明，一个独特的GMV协方差模式为每个OFC子区域。这些眶额皮层主要与前额叶和颞叶皮层、扣带回和杏仁核共变。此外，GMV的相关性的大多数OFC子区域是相似的性别和偏侧性，除了显着的偏侧性差异的OFCI。右侧OFCI与右侧下额叶皮层GMV相关性较强。使用高分辨率结构图像，我们为人类OFC建立了一个可靠的包裹方案，这可能为该区域的亚区域水平研究提供体内指导，并提高我们对人类OFC在亚区域水平的理解。©2014 Wiley Periodicals，Inc.
The human orbitofrontal cortex (OFC) is an enigmatic brain region that cannot be parcellated reliably using diffusional and functional magnetic resonance imaging (fMRI) because there is signal dropout that results from an inherent defect in imaging techniques. We hypothesise that the OFC can be reliably parcellated into subregions based on gray matter volume (GMV) covariance patterns that are derived from artefact‐free structural images. A total of 321 healthy young subjects were examined by high‐resolution structural MRI. The OFC was parcellated into subregions‐based GMV covariance patterns; and then sex and laterality differences in GMV covariance pattern of each OFC subregion were compared. The human OFC was parcellated into the anterior (OFCa), medial (OFCm), posterior (OFCp), intermediate (OFCi), and lateral (OFCl) subregions. This parcellation scheme was validated by the same analyses of the left OFC and the bilateral OFCs in male and female subjects. Both visual observation and quantitative comparisons indicated a unique GMV covariance pattern for each OFC subregion. These OFC subregions mainly covaried with the prefrontal and temporal cortices, cingulate cortex and amygdala. In addition, GMV correlations of most OFC subregions were similar across sex and laterality except for significant laterality difference in the OFCl. The right OFCl had stronger GMV correlation with the right inferior frontal cortex. Using high‐resolution structural images, we established a reliable parcellation scheme for the human OFC, which may provide an in vivo guide for subregion‐level studies of this region and improve our understanding of the human OFC at subregional levels.Hum Brain Mapp 36:538–548, 2015. ©2014 Wiley Periodicals, Inc.