Anticipation in the rodent head direction system can be explained by an interaction of head movements and vestibular firing properties.
Anticipation in the rodent head direction system can be explained by an interaction of head movements and vestibular firing properties.
复制标题
啮齿动物头部方向系统的预期可以通过头部运动和前庭发射特性的相互作用来解释。
DOI：
10.1152/jn.00233.2007
复制
发表时间：
2007
影响因子：
2.5
通讯作者：
vanRossum,MarkCW
中科院分区：
文献类型：
--
作者：
vanderMeer,MatthijsAA;Knierim,JamesJ;Yoganarasimha,D;Wood,EmmaR;vanRossum,MarkCW
啮齿类动物的头部方向(HD)系统编码动物头部在水平面上的方向，被认为是空间导航的关键。电生理记录研究表明，HD细胞可以预测动物的HD长达75-80ms。人们对这种预期的由来知之甚少。在这项模型研究中，我们对依赖于HD系统传入神经元的放电特性的HD预测提供了一种新的解释。通过结合前庭内侧核神经元中观察到的峰率适应和抑制后反弹，我们的模型在大鼠运动数据的大型语料库上产生了现实的预期。此外，HD预期在同一细胞的记录过程中、在主动运动和被动运动之间以及在不同研究之间有所不同。这种差异似乎与行为变量无关，也不能用早期的模型来解释。在目前的模型中，预期取决于头部运动的功率谱。通过与记录数据的直接比较，我们发现该模型可以解释60%-80%的观测到的预期变异性。我们的结论是，HD传入动力学和大鼠头运动的统计在HD预期的产生中是重要的。这一结果有助于理解HD系统的功能回路，并对HD预测的研究具有方法论意义。
The rodent head-direction (HD) system, which codes for the animal's head direction in the horizontal plane, is thought to be critically involved in spatial navigation. Electrophysiological recording studies have shown that HD cells can anticipate the animal's HD by up to 75–80 ms. The origin of this anticipation is poorly understood. In this modeling study, we provide a novel explanation for HD anticipation that relies on the firing properties of neurons afferent to the HD system. By incorporating spike rate adaptation and postinhibitory rebound as observed in medial vestibular nucleus neurons, our model produces realistic anticipation on a large corpus of rat movement data. In addition, HD anticipation varies between recording sessions of the same cell, between active and passive movement, and between different studies. Such differences do not appear to be correlated with behavioral variables and cannot be accounted for using earlier models. In the present model, anticipation depends on the power spectrum of the head movements. By direct comparison with recording data, we show that the model explains 60–80% of the observed anticipation variability. We conclude that HD afferent dynamics and the statistics of rat head movements are important in generating HD anticipation. This result contributes to understanding the functional circuitry of the HD system and has methodological implications for studies of HD anticipation.