Associations of risk factors in childhood with arterial stiffness 26 years later: the Hanzhong adolescent hypertension cohort
Associations of risk factors in childhood with arterial stiffness 26 years later: the Hanzhong adolescent hypertension cohort
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儿童期危险因素与26年后动脉硬化的关联：汉中青少年高血压队列
DOI：
10.1097/hjh.0000000000001242
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发表时间：
2017-05-01
影响因子：
4.9
通讯作者：
Wang, Yang
中科院分区：
文献类型：
--
作者：
Chu, Chao;Dai, Yi;Wang, Yang
目的：方法：1987年对陕西省汉中市农村地区4623名6-15岁学龄儿童进行基线调查。根据1987年、1989年和1992年三次独立测量的收缩压，将相同年龄和性别的连续收缩压≥ 75百分位数的病例归类为高血压组，而将收缩压<50百分位数的病例归类为正常血压组。该队列在26年后再次随访（2013年）。检测空腹血糖、血尿酸、血脂等血液生化指标。结果：随访率为71.6%。高血压组的高血压发生率较高（39.5%对18.0%，P
Objective: The relationship between childhood risk factors and long-term arterial stiffness was explored.Methods: A baseline survey was conducted in 4623 school children aged 6-15 years in rural areas of Hanzhong city, Shaanxi, in 1987. According to three independent measurements of SBP in 1987, 1989, and 1992, cases of the same age and sex with continuous SBP at least 75 percentile were classified as the high-blood pressure (BP) group, whereas those with SBP less than 50 percentile were classified as the normal-BP group. The cohort was followed up again after 26 years (in 2013). Blood biochemistry indexes, including fasting glucose, uric acid, and blood lipid, were measured. Brachial-ankle pulse wave velocity (baPWV) was recorded by noninvasive automatic waveform analyzer.Results: Follow-up rate was 71.6%. The high-BP group had a higher incidence of hypertension (39.5 vs. 18.0%, P