Population-based twin study of the effects of migration from Finland to Sweden on endothelial function and intima-media thickness
Population-based twin study of the effects of migration from Finland to Sweden on endothelial function and intima-media thickness
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DOI：
10.1161/01.atv.0000013313.70875.a7
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发表时间：
2002-05-01
影响因子：
8.7
通讯作者：
Raitakari, OT
中科院分区：
文献类型：
--
作者：
Jartti, L;Rönnemaa, T;Raitakari, OT
芬兰男性冠心病（CHD）死亡率高于瑞典男性。为了评估移民到CHD死亡率较低的国家对亚临床动脉粥样硬化的影响，我们测量了从芬兰移民到瑞典的双胞胎的早期功能和结构动脉粥样硬化血管变化。对74对年龄在42 ~ 69岁的男性双胞胎（20对单合子，54对双合子）进行常规CHD危险因素、肱动脉血流介导性扩张（FMD）、颈动脉内膜中层厚度和颈动脉顺应性测定，其中一对双胞胎在20年前永久移居瑞典。除舒张压和体脂百分比在瑞典较高外，冠心病危险因素无显著差异。在所有受试者中，瑞典的平均FMD无显著性升高（5.7+/-4.3%vs4.9 +/-4.2%，P =0.22），但在单卵双胞胎中，FMD差异非常显著（7.2+/-4.4vs3.7 +/-2.9%，P =0.003）。瑞典和芬兰之间的颈动脉内膜中层厚度或顺应性没有显著差异。我们的结论是，在芬兰单卵双胞胎的内皮功能是更好的双胞胎中，已迁移到一个国家，冠心病患病率较低。
Finnish men have higher coronary heart disease (CHD) mortality than Swedish men do. To assess the impact of migration to a country with lower CHD mortality on subclinical atherosclerosis, we measured early functional and structural atherosclerotic vascular changes in twins discordant for migration from Finland to Sweden. Conventional CHD risk factors, flow-mediated dilatation (FMD) of the brachial artery, carotid intima-media thickness, and carotid artery compliance were measured in 74 male twin pairs (20 monozygous, 54 dizygous), aged 42 to 69 years, in which co-one twin had migrated more than 20 years ago permanently to Sweden. There were no significant differences in CHD risk factors except for diastolic blood pressure and body fat percentage, which were higher in Sweden. In all subjects, mean FMD was non-significantly higher in Sweden (5.7+/-4.3% vs 4.9+/-4.2%, P=0.22), but in monozygous twins the difference in FMD was highly significant (7.2+/-4.4 vs 3.7+/-2.9%, P=0.003). There was no significant difference in intima-media thickness or carotid artery compliance between Sweden and Finland. We conclude that in Finnish monozygous twins the endothelial function is better among the twins that have migrated to a country with lower CHD prevalence.