ADRENERGIC AND CHOLINERGIC INNERVATION OF RAT URINARY-BLADDER
ADRENERGIC AND CHOLINERGIC INNERVATION OF RAT URINARY-BLADDER
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DOI：
10.1111/j.1748-1716.1975.tb05859.x
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
ELMER, M
中科院分区：
文献类型：
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作者：
ALM, P;ELMER, M
采用组织化学方法和神经刺激法研究了大鼠膀胱的自主神经支配。发现逼尿肌有稀疏的肾上腺素能神经支配。它被认为起源于长肾上腺素能神经元。三角区有丰富的肾上腺素能纤维供应，可能来源于短肾上腺素能神经元。在整个膀胱中发现了一致丰富的乙酰胆碱酯酶（AChE）阳性神经。节后交感神经去支配未引起膀胱内肾上腺素能或AChE阳性神经的可检测变化，而副交感神经去支配或去支配则导致肾上腺素能纤维完全消失。在副交感神经去中心化后，AChE阳性神经的数量明显减少，而在神经节后去神经支配后，AChE阳性神经的数量未被检测到。膀胱壁上既没有肾上腺素能细胞，也没有乙酰胆碱酯酶阳性的神经节细胞。电刺激腹下神经或骨盆神经节远端的骨盆神经引起逼尿肌收缩。六甲铵、二氢麦角胺或心得安对反应没有影响，但胍乙啶略微降低反应，阿托品降低约40%，eserine增强反应。对骨盆神经节近端的盆腔神经的刺激被六甲铵部分阻断。由此可见，大鼠膀胱主要由节后肾上腺素能纤维经盆腔神经供能，少量经胃下神经供能。可能胆碱能纤维主要通过盆腔神经进入膀胱，但也通过胃下神经，其细胞体在膀胱壁外，部分靠近盆腔神经节。
The autonomic innervation of the rat urinary bladder was studied using histochemical methods and nerve stimulations. A sparse adrenergic innervation of the detrusor muscle was found. It was supposed to originate from long adrenergic neurones. The trigonum area had a rich supply of adrenergic fibres, probably derived from short adrenergic neurones. A uniformly rich supply of acetylcholine‐esterase (AChE)‐positive nerves was found in the whole bladder. Postganglionic sympathetic denervation caused no detectable change of adrenergic or AChE‐positive nerves in the bladder, while parasympathetic decentralization or denervation produced a total disappearance of adrenergic fibres. The AChE‐positive nerves were appreciably reduced in number after parasympathetic decentralization and not detectable after postganglionic denervation. Neither adrenergic nor AChE‐positive ganglion cells could be demonstrated in the bladder wall. Electrical stimulation of the hypogastric nerves or the pelvic nerves distal to the pelvic ganglia elicited contraction of the detrusor muscle. The responses were not affected by hexamethonium, dihydroergotamine or propranolol but were slightly reduced by guanethidine, reduced to about 40% by atropine and potentiated by eserine. Stimulation of the pelvic nerve proximal to the pelvic ganglion was partially blocked by hexamethonium. It is concluded that the urinary bladder of the rat is supplied by postganglionic adrenergic fibres mainlyviathe pelvic nerves and only to a lesser extentviathe hypogastric nerves. Probably cholinergic fibres pass to the bladder mainlyviathe pelvic nerves but alsoviathe hypogastric nerves, having their cellbodies outside the bladder wall, partly proximal to the pelvic ganglia.