Neurodevelopment of HIV-exposed uninfected children in South Africa: outcomes from an observational birth cohort study
Neurodevelopment of HIV-exposed uninfected children in South Africa: outcomes from an observational birth cohort study
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DOI：
10.1016/s2352-4642(19)30250-0
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发表时间：
2019-11-01
影响因子：
36.4
通讯作者：
Donald, Kirsten A.
中科院分区：
文献类型：
--
作者：
Wedderburn, Catherine;Yeung, Shunmay;Donald, Kirsten A.
背景：众所周知，HIV感染会导致发育迟缓，但妊娠期HIV暴露而无感染对儿童发育的影响尚不清楚。我们比较了神经发育结果的艾滋病毒暴露未感染和艾滋病毒未暴露的儿童在他们的第一个2 years of life.Methods孕妇（>18岁）在20-28周的妊娠被纳入Drakenstein儿童健康队列研究，同时参加常规产前预约在两个城市周边的社区为基础的诊所在Paarl，南非。随访期间入组女性的活产纳入出生队列。母亲和婴儿按照当地指南接受产前和产后艾滋病毒检测和抗逆转录病毒治疗。在6个月龄的婴儿亚组和24个月龄的全队列中，使用Bayley婴幼儿发育量表第三版（BSID-III）进行发育评估，评估者对HIV暴露状态不知情。平均原始评分和被归类为延迟的儿童比例（评分
Background HIV infection is known to cause developmental delay, but the effects of HIV exposure without infection during pregnancy on child development are unclear. We compared the neurodevelopmental outcomes of HIV-exposed uninfected and HIV-unexposed children during their first 2 years of life.Methods Pregnant women (>18 years of age) at 20-28 weeks' gestation were enrolled into the Drakenstein Child Health cohort study while attending routine antenatal appointments at one of two pert-urban community-based clinics in Paarl, South Africa. Livebirths born to enrolled women during follow-up were included in the birth cohort. Mothers and infants received antenatal and postnatal HIV testing and antiretroviral therapy per local guidelines. Developmental assessments on the Bayley Scales of Infant and Toddler Development, third edition (BSID-III), were done in a subgroup of infants at 6 months of age, and in the full cohort at 24 months of age, with assessors masked to HIV exposure status. Mean raw scores and the proportions of children categorised as having a delay (scores