Outbreak of hospital infection caused by contaminated autoclaved fluids.
Outbreak of hospital infection caused by contaminated autoclaved fluids.
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DOI：
10.1016/s0140-6736(72)90981-6
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发表时间：
1972-06
期刊：
影响因子：
168.9
通讯作者：
I. Phillips;S. Eykyn;M. Laker
中科院分区：
文献类型：
--
作者：
I. Phillips;S. Eykyn;M. Laker
1971年4月至1972年1月间，伦敦圣托马斯医院40例病人发生了感染性疾病，通常为败血症或泌尿道感染。爆发的源头是药房制造的软化、去离子和蒸馏水，并在整个医院广泛使用。当用于在快速冷却高压灭菌器中冷却胃肠外和其他灭菌液体的瓶子时，这些水通常留在带盖箔密封件下方的塞子上，当塞子被扰动时，水进入瓶子并污染其内容物。在冷却循环期间，水可能直接进入一些瓶子。输注这些受污染的溶液可能是大多数感染的原因。来自同一来源的水也用于机械加湿器的加湿器中，导致机器的普遍污染和患者呼吸道的定植。
Between April, 1971, and January, 1972,Summary40 patients in St. Thomas's Hospital, London, acquired infections, usually bacteræmia or urinary or respiratory-tract infections, caused byPseudomonas thomasii,a previously undescribed organism related toP. cepacia.The source of the outbreak was softened, deionised, and distilled water manufactured in the pharmacy and widely used throughout the hospital. When used for cooling bottles of parenteral and other sterilised fluids in a rapid-cooling autoclave, this water often remained on the bung beneath the crimped-foil seal, entering the bottle and contaminating its contents when the bung was disturbed. Water may have entered some bottles directly during the cooling-cycle. Infusion of these contaminated solutions was probably the cause of most of the infections. Water from the same source was also used in the humidifiers of mechanical ventilators, resulting in general contamination of the machines and colonisation of patients' respiratory tracts.