The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
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DOI：
10.1038/35000034
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发表时间：
2000-02-01
影响因子：
21.3
通讯作者：
de Herreros, AG
中科院分区：
文献类型：
--
作者：
Batlle, E;Sancho, E;de Herreros, AG
黏附蛋白E -钙黏蛋白在上皮形态发生过程中起核心作用。在上皮肿瘤进展的晚期获得转移潜能期间，该蛋白的表达下调。有证据表明在此过程中E -钙黏蛋白基因的表达存在转录阻断。在此我们表明，由成纤维细胞和一些E -钙黏蛋白阴性的上皮肿瘤细胞系表达的转录因子Snail与人类E -钙黏蛋白启动子中存在的三个E -盒结合，并抑制E -钙黏蛋白的转录。在缺乏E -钙黏蛋白的上皮癌细胞系中抑制Snail功能可恢复E -钙黏蛋白基因的表达。
The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of E-cadherin gene expression in this process. Here we show that the transcription factor Snail, which is expressed by fibroblasts and some E-cadherin-negative epithelial tumour cell lines, binds to three E-boxes present in the human E-cadherin promoter and represses transcription of E-cadherin, Inhibition of Snail function in epithelial cancer cell lines lacking E-cadherin protein restores the expression of the E-cadherin gene.