CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats.
CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats.
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CART 肽可增加自由活动大鼠中缝背侧和伏核中的 5-羟色胺。
DOI：
10.1016/j.neulet.2007.02.049
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发表时间：
2007
影响因子：
2.5
通讯作者：
Tao,Rui
中科院分区：
文献类型：
--
作者：
Ma,Zhiyuan;Pearson,Elliot;Tao,Rui
可卡因和安非他明调节的转录肽（CART）与抗抑郁作用有关。这可能与中枢神经系统中5-羟色胺（5-HT）有关。本研究的目的是研究CART肽对中缝背核（DRN）和延髓核（NAcc）细胞外5-HT的影响，使用微透析方法在自由行为的大鼠。在DRN中反向输注CART 61 − 102可使DRN中5-HT浓度（10-100μM）依赖性增加。类似地，输注到DRN和NAcc中的CART 62 -76（10-100μM）分别升高DRN和NAcc中的5-HT。因此，CART增加DRN和NAcc中的细胞外5-HT。此外，在DRN中输注CART 62 -76（100μM）导致NAcc中5-HT的显著增加，这意味着存在负责去极化依赖性释放的CART受体。总之，本研究的结果表明，CART肽可能通过增加细胞外5-HT而具有抗抑郁作用。
Cocaine and amphetamine-regulated transcript peptides (CART) are implicated in the antidepressant effect. This may involve in 5-hydroxytryptamine (5-HT) in the CNS. The aim of the present studies was to investigate the effect of CART peptides on extracellular 5-HT in the dorsal raphe nucleus (DRN) and nucleus accumbens (NAcc) using a microdialysis approach in freely behaving rats. Reverse infusion of CART61−102in the DRN produced a concentration (10–100μM) -dependent increase in 5-HT in the DRN. Similarly, CART62–76(10–100μM) infused into the DRN and NAcc elevated 5-HT in the DRN and NAcc, respectively. Thus, CART increases extracellular 5-HT in both the DRN and NAcc. In addition, infusion of CART62–76(100μM) in the DRN produced a significant increase in 5-HT in the NAcc, implying an existence of CART receptors responsible for the depolarization-dependent release. In summary, the results of the present studies suggest that CART peptides may have an antidepressant effect through increases in extracellular 5-HT.