Palladium/di-1-adamantyl-n-butylphosphine-catalyzed reductive carbonylation of aryl and vinyl halides
Palladium/di-1-adamantyl-n-butylphosphine-catalyzed reductive carbonylation of aryl and vinyl halides
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DOI：
10.1016/j.tet.2007.02.043
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发表时间：
2007-07-02
期刊：
影响因子：
2.1
通讯作者：
Beller, Matthias
中科院分区：
文献类型：
--
作者：
Brennfuhrer, Anne;Neumann, Helfried;Beller, Matthias
开发了一种通用、高效的钯催化的低负载量(0.5mol%Pd或以下)的还原羰化反应。芳基和杂芳基溴化物在钯/二-1-金刚烷基-正丁基膦的存在下，在合成气的常压下，甲酰化反应顺利进行，生成相应的芳香醛，产率高，选择性好。此外，乙烯基卤化物在类似的条件下反应生成α，β-不饱和醛，产率很高。(C)2007爱思唯尔有限公司。保留所有权利。
A general and efficient palladium-catalyzed reductive carbonylation with low catalyst loadings (0.5 mol% Pd or below) has been developed. The formylation of aryl and heteroaryl bromides proceeds smoothly in the presence of palladium/di-1-adamantyl-n-butylphosphine at ambient pressure of synthesis gas to afford the corresponding aromatic aldehydes in good yields and excellent selectivity. In addition, vinyl halides react under similar conditions to form alpha,beta-unsaturated aldehydes in good yield. (c) 2007 Elsevier Ltd. All rights reserved.