Genomic analysis establishes correlation between growth and laryngeal neuropathy in Thoroughbreds.
Genomic analysis establishes correlation between growth and laryngeal neuropathy in Thoroughbreds.
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DOI：
10.1186/1471-2164-15-259
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发表时间：
2014-04-03
期刊：
影响因子：
4.4
通讯作者：
Robinson NE
中科院分区：
文献类型：
--
作者：
Boyko AR;Brooks SA;Behan-Braman A;Castelhano M;Corey E;Oliveira KC;Swinburne JE;Todhunter RJ;Zhang Z;Ainsworth DM;Robinson NE
Equine recurrent laryngeal neuropathy (RLN) is a bilateral mononeuropathy with an unknown pathogenesis that significantly affects performance in Thoroughbreds. A genetic contribution to the pathogenesis of RLN is suggested by the higher prevalence of the condition in offspring of RLN-affected than unaffected stallions. To better understand RLN pathogenesis and its genetic basis, we performed a genome-wide association (GWAS) of 282 RLN-affected and 268 control Thoroughbreds. We found a significant association of RLN with the LCORL/NCAPG locus on ECA3 previously shown to affect body size in horses. Using height at the withers of 505 of these horses, we confirmed the strong association of this locus with body size, and demonstrated a significant phenotypic and genetic correlation between height and RLN grade in this cohort. Secondary genetic associations for RLN on ECA18 and X did not correlate with withers height in our cohort, but did contain candidate genes likely influencing muscle physiology and growth: myostatin (MSTN) and integral membrane protein 2A (ITM2A). This linkage between body size and RLN suggests that selective breeding to reduce RLN prevalence would likely reduce adult size in this population. However, our results do not preclude the possibility of modifier loci that attenuate RLN risk without reducing size or performance, or that the RLN risk allele is distinct but tightly linked to the body size locus on ECA3. This study is both the largest body size GWAS and the largest RLN GWAS within Thoroughbred horses to date, and suggests that improved understanding of the relationship between genetics, equine growth rate, and RLN prevalence may significantly advance our understanding and management of this disease.
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影响因子：
3.3
作者：
Bower, M. A.;Campana, M. G.;Binns, M.
通讯作者：
Binns, M.
影响因子：
1.4
作者：
GOULDEN, BE;ANDERSON, LJ;CAHILL, JI
通讯作者：
CAHILL, JI
影响因子：
2.2
作者：
Hahn, C. N.;Matiasek, K.;Mayhew, I. G.
通讯作者：
Mayhew, I. G.
影响因子：
4.5
作者：
Petersen JL;Mickelson JR;Rendahl AK;Valberg SJ;Andersson LS;Axelsson J;Bailey E;Bannasch D;Binns MM;Borges AS;Brama P;da Câmara Machado A;Capomaccio S;Cappelli K;Cothran EG;Distl O;Fox-Clipsham L;Graves KT;Guérin G;Haase B;Hasegawa T;Hemmann K;Hill EW;Leeb T;Lindgren G;Lohi H;Lopes MS;McGivney BA;Mikko S;Orr N;Penedo MC;Piercy RJ;Raekallio M;Rieder S;Røed KH;Swinburne J;Tozaki T;Vaudin M;Wade CM;McCue ME
通讯作者：
McCue ME
影响因子：
3.7
作者：
Bongiorni S;Mancini G;Chillemi G;Pariset L;Valentini A
通讯作者：
Valentini A