Joint testing of donor and recipient genetic matching scores and recipient genotype has robust power for finding genes associated with transplant outcomes.
Joint testing of donor and recipient genetic matching scores and recipient genotype has robust power for finding genes associated with transplant outcomes.
复制标题
DOI：
10.1002/gepi.22349
复制
发表时间：
2020-11
影响因子：
2.1
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Arthur VL;Guan W;Loza BL;Keating B;Chen J
Genetic matching between transplant donor and recipient pairs has traditionally focused on the HLA regions of the genome, but recent studies suggest that matching for non-HLA regions may be important as well. We assess four genetic matching scores for use in association analyses of transplant outcomes. These scores describe genetic ancestry distance using IBS, or genetic incompatibility or mismatch of the two genomes and therefore may reflect different underlying biological mechanisms for donor and recipient genes to influence transplant outcomes. Our simulation studies show that jointly testing these scores with the recipient genotype is a powerful method for preliminary screening and discovery of transplant outcome related SNPs and gene regions. Following these joint tests with marginal testing of the recipient genotype and matching score separately can lead to further understanding of the biological mechanisms behind transplant outcomes. In addition, we present results of a liver transplant data analysis that show joint testing can detect SNPs significantly associated with acute rejection in liver transplant.
登录
查看更多内容
影响因子：
7.3
作者：
Pineda S;Sigdel TK;Chen J;Jackson AM;Sirota M;Sarwal MM
通讯作者：
Sarwal MM
分析方法检测出孕产妇/胎儿基因型不兼容，从而增加了先兆子痫的风险。
影响因子：
--
作者：
Parimi, Neeta;Tromp, Gerard;Kuivaniemi, Helena;Nien, Jyh Kae;Gomez, Ricardo;Romero, Roberto;Goddard, Katrina A. B.
通讯作者：
Goddard, Katrina A. B.
影响因子：
12.3
作者：
Li YR;van Setten J;Verma SS;Lu Y;Holmes MV;Gao H;Lek M;Nair N;Chandrupatla H;Chang B;Karczewski KJ;Wong C;Mohebnasab M;Mukhtar E;Phillips R;Tragante V;Hou C;Steel L;Lee T;Garifallou J;Guettouche T;Cao H;Guan W;Himes A;van Houten J;Pasquier A;Yu R;Carrigan E;Miller MB;Schladt D;Akdere A;Gonzalez A;Llyod KM;McGinn D;Gangasani A;Michaud Z;Colasacco A;Snyder J;Thomas K;Wang T;Wu B;Alzahrani AJ;Al-Ali AK;Al-Muhanna FA;Al-Rubaish AM;Al-Mueilo S;Monos DS;Murphy B;Olthoff KM;Wijmenga C;Webster T;Kamoun M;Balasubramanian S;Lanktree MB;Oetting WS;Garcia-Pavia P;MacArthur DG;de Bakker PI;Hakonarson H;Birdwell KA;Jacobson PA;Ritchie MD;Asselbergs FW;Israni AK;Shaked A;Keating BJ
通讯作者：
Keating BJ
影响因子：
2.7
作者：
Dai, James Y.;Kooperberg, Charles;Prentice, Ross L.
通讯作者：
Prentice, Ross L.
影响因子：
8.9
作者：
Morris, Alanna A.;Kalogeropoulos, Andreas P.;Butler, Javed
通讯作者：
Butler, Javed