Atherosclerotic Plaque Progression in Carotid Arteries: Monitoring with High-Spatial-Resolution MR Imaging-Multicenter Trial
Atherosclerotic Plaque Progression in Carotid Arteries: Monitoring with High-Spatial-Resolution MR Imaging-Multicenter Trial
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DOI：
10.1148/radiol.2523081798
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发表时间：
2009-09-01
期刊：
影响因子：
19.7
通讯作者：
Saloner, David
中科院分区：
文献类型：
--
作者：
Boussel, Loic;Arora, Sandeep;Saloner, David
目的：估计血管壁体积的进展，在160例患者的颈动脉的年化率，通过使用磁共振（MR）成像，并建立一个分数的研究，具有可接受的图像quality.Materials和方法：研究程序和同意书进行了审查和批准，每个网站的机构审查委员会。所有联合S.研究中心按照HIPAA要求进行了本研究的所有阶段。获得每位参与者的书面同意。在6个中心招募了160例颈动脉直径狭窄大于50%的患者，在基线和1年后使用高空间分辨率1.5 T MR成像进行颈动脉前瞻性成像。排除了图像质量不可接受的研究。在非增强T1加权图像上测量动脉粥样硬化体积的定量变化。多元线性回归分析被用来关联进展与几个临床因素，包括他汀类therapy.Results：所有160例患者完成基线和随访研究。在这些研究中，67.5%的图像质量被认为可用于定量分析。排斥反应的原因是运动（46%），深位置的颈动脉（22%），低分叉的颈动脉（13%），和“其他”（19%）。血管壁容积的平均年变化为2.31% +/- 10.88（标准差）（P = 0.014）。在1年随访时，未接受他汀类药物治疗的患者的血管壁体积比接受他汀类药物治疗的患者增加更快：分别为7.87% +/- 13.58% vs 1.14% +/-9.9%（P = .029）.结论：多中心研究结果的评价表明，定量评价颅外颈动脉血管壁体积的进展是可行的1.5 T MR成像，尽管由于患者运动或体质的限制。在既往有颈动脉疾病的患者中，接受他汀类药物治疗的患者血管壁容积增加速度较慢。(C)RSNA，2009年
Purpose: To estimate the annualized rate of progression of vessel-wall volume in the carotid arteries in 160 patients by using magnetic resonance (MR) imaging and to establish the fraction of studies that have acceptable image quality.Materials and Methods: The study procedures and consent forms were reviewed and approved by each site's institutional review board. All U. S. study sites conducted all phases of this study in compliance with HIPAA requirements. Written consent was obtained from each participant. One hundred sixty patients with greater than 50% narrowing of the diameter of the carotid artery were recruited at six centers for prospective imaging of the carotid arteries at baseline and 1 year later by using high-spatial-resolution, 1.5-T MR imaging. Studies with unacceptable image quality were excluded. Quantitative changes in atheroma volume were measured on unenhanced T1-weighted images. A multiple linear regression analysis was used to correlate progression with several clinical factors, including statin therapy.Results: All 160 patients completed both baseline and follow-up studies. Of these studies, 67.5% were deemed to have image quality that was acceptable for quantitative analysis. The causes of rejection were motion (46%), deep location of the carotid artery (22%), low bifurcation of the carotid artery (13%), and "other" (19%). The mean annual change in vessel-wall volume was 2.31% +/- 10.88 (standard deviation) (P = .014). At 1-year follow-up, vessel-wall volumes in patients not receiving statin therapy had increased faster compared with those in patients receiving statin therapy: 7.87% +/- 13.58% vs 1.14% +/- 9.9%, respectively (P = .029).Conclusion: Evaluation of results of a multicenter study indicates that quantitative evaluation of the progression of volume of extracranial carotid vessel walls is feasible with 1.5-T MR imaging despite limitations due to patient motion or habitus. In patients who had preexisting carotid disease, the rate of increase in vessel-wall volume was slower in patients receiving statin therapy. (C) RSNA, 2009