Development of a novel method for synthesis of a polymeric ultrasound contrast agent
Development of a novel method for synthesis of a polymeric ultrasound contrast agent
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DOI：
10.1002/jbm.a.10586
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发表时间：
2003-08-01
影响因子：
4.9
通讯作者：
Wheatley, MA
中科院分区：
文献类型：
--
作者：
El-Sherif, DM;Wheatley, MA
医学超声是一种非常有价值的诊断工具，特别是与其他成像方式相比。它是一种无创、实时、便携、与X射线相比非常安全的方法，并且相对于磁共振成像便宜。然而，超声在区分病变组织和正常组织的能力方面是有限的。这种限制导致了造影剂的发展。我们已经生产了新型的聚（乳酸-羟基乙酸）空气填充的微胶囊，以及作为超声造影剂，给予高达24和25分贝的增强时，在5和7.5 MHz的医疗成像范围内的声，分别。通过修改双乳液方法以将樟脑包封在油相中并将碳酸铵包封在水相中来制造胶囊，并且随后使包封的材料升华，留下能够在其位置填充气体的空隙。的表面活性剂，聚乙烯醇，溶液温度的作用，进行了研究，发现在胶囊的形态中发挥重要作用，改变他们的声学响应。(C)2003 Wiley Periodicals，Inc.
Medical ultrasound is a highly valuable diagnostic tool, especially when compared with other imaging modalities. It is a noninvasive, real-time, portable, extremely safe method compared with X-ray and inexpensive relative to magnetic resonance imaging. However, ultrasound is limited in its ability to distinguish between diseased and normal tissue. This limitation has led to the development of contrast agents. We have produced novel poly (lactic-co-glycolic) acid air-filled microcapsules that work well as ultrasound contrast agents, giving up to 24 and 25 dB enhancement when insonated in the medical imaging range at 5 and 7.5 MHz, respectively. The capsules were fabricated by modifying a double emulsion method to encapsulate camphor in the oil phase and ammonium carbonate in the aqueous phase, and later sublime the encapsulated material, leaving voids capable of being filled with a gas in their place. The role of the surfactant, poly vinyl alcohol, solution temperature, was studied and found to play an important role in the morphology of the capsules, altering their acoustic response. (C) 2003 Wiley Periodicals, Inc.