Therapy of herpes zoster with oral acyclovir.
Therapy of herpes zoster with oral acyclovir.
复制标题
口服阿昔洛韦治疗带状疱疹。
DOI：
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发表时间：
1988
影响因子：
5.9
通讯作者：
P. Mcguirt
中科院分区：
文献类型：
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作者：
J. Huff;B. Bean;H. Balfour;O. Laskin;J. Connor;L. Corey;Y. Bryson;P. Mcguirt
口服阿昔洛韦治疗带状疱疹已在双盲，安慰剂对照试验中进行了研究，两种剂量，400毫克和800毫克，每天五次，为期10天。与安慰剂接受者相比，高剂量阿昔洛韦接受者的病毒脱落期显著缩短，结痂50%的时间显著加快，愈合50%的时间显著加快，治疗两天后，新病变形成的频率显著降低。阿昔洛韦接受者的急性疼痛的持续时间和严重程度较低，疼痛严重程度的差异在第3天和第10天之间达到统计学显著性（p = 0.03），并与新病变形成的治疗差异相关。在400毫克每天五次剂量方案的研究中，阿昔洛韦和安慰剂接受者之间的差异并不显著。在高剂量研究中对接受者进行了6个月的随访，阿昔洛韦接受者比安慰剂接受者经历了更少的带状疱疹后疼痛;疼痛患病率的差异在随访的前三个月中对于持续性疼痛的存在最为显着。口服阿昔洛韦在这些剂量似乎是免费的不良反应。总之，口服阿昔洛韦800毫克，每日5次，连续10天治疗急性带状疱疹优于每日5次口服阿昔洛韦400毫克，上级，并有利地改变了病程。
Oral acyclovir therapy for herpes zoster has been studied in double-blind, placebo-controlled trials of two dosages, 400 mg and 800 mg five times per day for 10 days. Compared with placebo recipients, recipients of the high-dosage acyclovir experienced a significantly shortened period of viral shedding, significantly accelerated time to 50 percent scabbing, significantly accelerated time to 50 percent healing, and after two days of therapy, significantly less frequent formation of new lesions. The duration and severity of acute pain were less in acyclovir recipients, with differences in pain severity achieving statistical significance (p = 0.03) between Days 3 and 10 and correlating with the treatment differences in new lesion formation. In studies of the 400 mg five times per day dose schedule, differences between acyclovir and placebo recipients were not significant. In a six-month follow-up of recipients in the higher dosage study, the acyclovir recipients experienced less post-zoster pain than placebo recipients; differences in the prevalence of pain were most significant for the presence of a persistent pain in the first three months of follow-up. Oral acyclovir at these dosages appears to be free of adverse reactions. In summary, oral acyclovir at a dosage of 800 mg five times per day for 10 days for treatment of acute herpes zoster is superior to 400 mg five times per day and favorably alters the course of the disease.