An expanding explanation for the ascending limb of muscle's active force-length relationship.
An expanding explanation for the ascending limb of muscle's active force-length relationship.
复制标题
对上升肢肌肉主动力与长度关系的扩展解释。
DOI：
10.1016/j.bpj.2022.04.014
复制
发表时间：
2022
影响因子：
3.4
通讯作者：
Campbell,KennethS
中科院分区：
文献类型：
--
作者：
Campbell,KennethS
Many readers of this article will have taken, or perhaps taught, a systems-based physiology class. These often cover the material at a fast pace. As an example, at the University of Kentucky, I am allotted two hours to teach the medical students “all” of muscle physiology. We cover muscle’s length-tension relationship on slide seven. I explain that active force drops as filament overlap decreases on the descending limb, and that there is a plateau where the effective overlap does not change because of the thick filaments’ bare zones. I also explain that the ascending limb is critically important for cardiac muscle and, while the mechanism is poorly understood, likely reflects actin filaments from one half-sarcomere interfering with those from the other. It was not until I read the fascinating work of Rockenfeller, Günther, and Hooper in this issue of Biophysical Journal (
