Serum Antioxidant Concentrations and Metabolic Syndrome Are Associated among U.S. Adolescents in Recent National Surveys
Serum Antioxidant Concentrations and Metabolic Syndrome Are Associated among U.S. Adolescents in Recent National Surveys
复制标题
DOI：
10.3945/jn.112.160416
复制
发表时间：
2012-09-01
影响因子：
4.2
通讯作者：
Zonderman, Alan B.
中科院分区：
文献类型：
--
作者：
Beydoun, May A.;Canas, J. Atilio;Zonderman, Alan B.
特定的微量营养素，包括视黄醇、视黄酸酯、类胡萝卜素、β-胡萝卜素、β-胡萝卜素(顺式+反式)、p-隐黄质、叶黄素+玉米黄质和总番茄红素]、维生素E和维生素C具有抗炎和抗氧化作用，这些特性表明可以减少氧化应激，这是许多慢性疾病发病过程中的一个伴随过程。目前尚不清楚它们是否与美国青少年人群中代谢综合征(METS)的发生有关。METS由国际糖尿病联合会(IDF)标准定义。其他依赖于血液测量的非METS结果是HOMA-IR升高、C反应蛋白(CRP)和高尿酸血症。我们使用NHANES 2001-2006(n=782-4285)的横断面数据，在12-19岁的伽马青少年中测试了血清抗氧化剂和METS结果之间的相关性。据估计，IDF Mets在男孩中的流行率为7%，在女孩中为3%。在调整后的模型中，患有甲硫氨酸的青少年与没有服用甲硫氨酸的青少年相比，类胡萝卜素浓度一直较低。总类胡萝卜素与HOMA-IR、CRP呈负相关。维生素C与尿酸水平和蛋氨酸二次代谢产物呈负相关，视黄醇+视黄酸酯与C反应蛋白呈负相关，与尿酸、HOMA-IR和蛋氨酸二元代谢产物呈正相关。维生素E与蛋氨酸代谢综合征无关，特别是在控制了血清胆固醇和甘油三酯之后。总而言之，在美国青少年中，血清类胡萝卜素浓度与METS状态、HOMA-IR和CRP呈负相关，而血清维生素C与METS状态和血清尿酸呈负相关。维生素E与蛋氨酸没有一致的相关性，而视黄醇+视黄酸酯与HOMA-IR、尿酸和蛋氨酸呈正相关，而与C反应蛋白呈负相关。这些联系需要进一步研究。J.Nutr.142：1693-1704,2012。
Specific micronutrients, including retinol, retinyl esters, carotenoids beta-carotene, delta-carotene (cis+trans), p-cryptoxanthin, lutein+zeaxanthin, and total lycopene], vitamin E, and vitamin C have antiinflammatory and antioxidant effects, properties shown to reduce oxidative stress, a process that accompanies the pathogenesis of many chronic diseases. It is still largely unknown whether they are associated with the occurrence of metabolic syndrome (MetS) in the adolescent U.S. population. MetS was defined by the International Diabetes Federation (IDF) criteria. Other non-MetS outcomes relying on blood measurements were elevated HOMA-IR, C-reactive protein (CRP), and hyperuricemia. We tested associations between serum antioxidants and MetS outcomes among adolescents aged 12-19 gamma using cross-sectional data from NHANES 2001-2006 (n = 782-4285). IDF MetS prevalence was estimated at 7% among boys and 3% among girls. In adjusted models, adolescents with MetS had consistently lower carotenoid concentrations compared with their counterparts without MetS. Total carotenoids were also inversely related to HOMA-IR and CRP. Vitamin C was inversely related to uric acid level and MetS binary outcome, Retinol+retinyl esters exhibited an inverse relationship with CRP and a positive relationship with uric acid and HOMA-IR as well as MetS binary outcome. Vitamin E had no association with MetS, particularly after controlling for serum cholesterol and TG. In conclusion, among U.S. adolescents, serum carotenoid concentrations were inversely associated with MetS status, HOMA-IR, and CRP, whereas serum vitamin C was inversely related to MetS status and serum uric acid. Vitamin E had no consistent association with MetS, whereas retinol+retinyl esters had a positive relationship with HOMA-IR, uric acid, and MetS, while being inversely related to CRP. These associations need further study. J. Nutr. 142: 1693-1704,2012.