[Influence of clinical characteristics on health-related quality of life after mid-low rectal cancer surgery].
[Influence of clinical characteristics on health-related quality of life after mid-low rectal cancer surgery].
复制标题
DOI：
10.3760/cma.j.issn.0529-5815.2012.12.001
复制
发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Xin-xin Li;Xin-ming Song;Zhi-hui Chen;Ming-zhe Li;Dong-lian Chen;Ying Xu;W. Zhan;Yu-Long He
中科院分区：
文献类型：
--
作者：
Xin-xin Li;Xin-ming Song;Zhi-hui Chen;Ming-zhe Li;Dong-lian Chen;Ying Xu;W. Zhan;Yu-Long He
目的探讨中低位直肠癌根治术后无病生存者的健康相关生活质量。方法采用欧洲癌症研究与治疗组织QLQ-C30和CR-38问卷对2002年8月至2011年2月间收治的330例直肠癌患者进行回顾性横断面调查。通过单因素和多因素回归分析，评估和比较临床特征对HRQL的影响。结果共收到有效问卷204份。在情感功能(M(50)=91.67，U=2668.5，P=0.026)、社会功能(M(50)=83.33，U=2095.5，P<；0.001)、经济困难(M(50)=0，U=2240.5，P<；0.001)和身体形象(M(50)=88.89，U=2507.0，P=0.013)方面，有吻合口的患者比无吻合口的患者更易受到影响。仅在便秘量表(M(50)=14.29，U=2376.0，P=0.001)中，无吻合口患者得分较高。不同术式的分析与吻合口的分析是平行的。有并发症的患者在呼吸困难(M(50)=0，U=1505.0，P<；情绪功能(M(50)=83.33，U=1608.5，P=0.001)、认知功能(M(50)=66.67，U=1612.5，P=0.010)、身体形象(M(50)=66.67，U=1608.5，P=0.010)。P=0.012)。在我们的研究中，直肠癌手术后的HRQOL随着时间的推移而改善。多因素分析显示，吻合口和术后时间是最显著的影响因素。与较差的经济状况相关的变量是术后月数较少、并发症的发生和造口的存在。结论不同临床特征对中国中低位直肠癌根治术后患者的生存质量有显著影响。
OBJECTIVE The present study aims to investigate health-related quality of life (HRQOL) in disease-free survivors after radical surgery for mid-low rectal cancer. METHODS A retrospective cross-sectional study was performed in patients with rectal cancer who underwent primary surgery between August 2002 and February 2011 by use of the European Organization for Research and Treatment of Cancer QLQ-C30 and CR-38 questionnaires (n = 330). The impact of clinical characteristics on HRQoL were assessed and compared by univariate and multivariate regression analyses. RESULTS Two hundred and four effective responses were received. Patients with stoma were more impaired in HRQoL than those without stoma, especially in the field of social psychology, such as emotional function (M(50) = 91.67, U = 2668.5, P = 0.026), social function (M(50) = 83.33, U = 2095.5, P < 0.001), financial difficulties (M(50) = 0, U = 2240.5, P < 0.001) and body image (M(50) = 88.89, U = 2507.0, P = 0.013). Only in the constipation scale (M(50) = 14.29, U = 2376.0, P = 0.001), nonstoma patients had a better score. The analysis in different types of surgical procedure paralleled those of stoma. Patients with complication had a poorer function in some symptom scales such as dyspnoea (M(50) = 0, U = 1505.0, P < 0.001), gastro-intestinal symptom (M(50) = 6.67, U = 1766.0, P = 0.034) and financial difficulties (M(50) = 33.33, U = 1795.5, P = 0.044), and in some functioning scales such as emotional function (M(50) = 83.33, U = 1608.5, P = 0.009), cognitive function (M(50) = 66.67, U = 1612.5, P = 0.010) and body image (M(50) = 66.67, U = 1617.0, P = 0.012). In our study, HRQoL after rectal cancer surgery improved with time. Our multivariate analysis displayed that stoma and postoperative time were the most significant characteristics. Variables associated with worse financial status were less postoperative months, occurrence of complications and presence of stoma. CONCLUSIONS Different scales of HRQoL in patients of China after curative surgery for mid-low rectal cancer are significantly influenced by different clinical characteristics.