Initial assessment of image quality for low-dose PET: evaluation of lesion detectability
Initial assessment of image quality for low-dose PET: evaluation of lesion detectability
复制标题
DOI：
10.1088/0031-9155/60/14/5543
复制
发表时间：
2015-07-21
影响因子：
3.5
通讯作者：
Conti, Maurizio
中科院分区：
文献类型：
--
作者：
Schaefferkoetter, Joshua D.;Yan, Jianhua;Conti, Maurizio
在研究低剂量PET成像在筛查应用中的潜力的背景下，我们开发了评估小病变可检测性的方法，作为扫描中计数的函数。我们在这里介绍了我们的方法和使用结核病病例的初步验证。17名表现弥漫性高代谢肺病变的患者的FDG-PET数据被选为研究对象，包括广泛的病变大小和对比。在PET列表模式中通过随机丢弃事件来模拟减少的剂量，并在每个模拟剂量下生成并重建10个实现。根据包含的真实事件的数量，将数据分成9个类别，从>；40M到
In the context of investigating the potential of low-dose PET imaging for screening applications, we developed methods to assess small lesion detectability as a function of the number of counts in the scan. We present here our methods and preliminary validation using tuberculosis cases. FDG-PET data from seventeen patients presenting diffuse hyper-metabolic lung lesions were selected for the study, to include a wide range of lesion sizes and contrasts. Reduced doses were simulated by randomly discarding events in the PET list mode, and ten realizations at each simulated dose were generated and reconstructed. The data were grouped into 9 categories determined by the number of included true events, from >40 M to