The Critical Role of Calpain in Cell Proliferation.
The Critical Role of Calpain in Cell Proliferation.
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DOI：
10.4172/2167-7956.1000112
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
L. Kovács;Yun Su
中科院分区：
文献类型：
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作者：
L. Kovács;Yun Su
钙蛋白酶是一个保守的钙依赖性、胞质、中性半胱氨酸蛋白酶家族。该家族最具特征的成员是广泛表达的钙蛋白酶1和钙蛋白酶2。它们对靶蛋白进行受控的蛋白水解。这些酶的调节包括自溶、钙、作为翻译后修饰的磷酸化，以及分别与钙蛋白酶抑制剂、磷脂或激活蛋白的结合。钙蛋白酶参与许多生理和病理过程。它们在多种哺乳动物细胞类型的细胞增殖、分化和迁移中具有重要作用，有助于血管生成、血管重塑和癌症的发展。因此，了解钙蛋白酶信号传导的确切机制可以为这些过程提供治疗方法。
Calpain is a conserved family of calcium-dependent, cytosolic, neutral cysteine proteases. The best characterized members of the family are the ubiquitously expressed calpain 1 and calpain 2. They perform controlled proteolysis of their target proteins. The regulation of these enzymes includes autolysis, calcium, phosphorylation as a posttranslational modification, and binding of calpastatin, phospholipids or activator proteins, respectively. Calpain are implicated in many physiological and pathological processes. They have significant role in the cell proliferation, differentiation and migration in a variety of mammalian cell types, contributing to the development of angiogenesis, vascular remodeling, and cancer. Therefore the knowledge of the precise mechanism of calpain signaling could provide therapeutic approaches in these processes.