The antioxidative function, preventive action on disease and utilization of proanthocyanidins
The antioxidative function, preventive action on disease and utilization of proanthocyanidins
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DOI：
10.1002/biof.552210140
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发表时间：
2004-01-01
期刊：
影响因子：
6
通讯作者：
Ariga, T
中科院分区：
文献类型：
--
作者：
Ariga, T
原花青素是多酚类物质的一种，广泛分布于植物界。大多数人通过红酒和蔓越莓汁等食物摄入微量的原花青素。然而，原花青素的功能特性却知之甚少。自1983年以来，我们对原花青素的抗氧化功能、疾病预防作用及开发利用进行了研究。在水溶液中，原花青素的抗氧化活性远强于维生素C和维生素E。其抗氧化作用的机制涉及自由基清除，淬火和酶抑制作用。用动物试验研究了原花青素对与活性氧有关的疾病的预防作用。富含原花青素的葡萄籽提取物对动脉粥样硬化、胃溃疡、大肠癌、白内障和糖尿病等疾病有预防作用。在人体干预试验中，葡萄籽提取物被证明对运动后人体血浆中脂质过氧化物的增加和训练后肌肉疲劳具有预防作用。随后开发了原花青素产品的用途和制造技术。这些产品作为食品添加剂中的抗氧化剂，营养补充剂和化妆品中的成分推出。
Proanthocyanidins, which belong to a class of polyphenols, are widely distributed throughout the plant kingdom. Most people ingest trace amounts of proanthocyanidins through foods such as red wine and cranberry juice. However, the functional properties of proanthocyanidins have been little understood. Since 1983, we have studied the antioxidative functions, preventive actions on diseases and utilization of proanthocyanidins. The antioxidative activities of proanthocyanidins were found to be much stronger than vitamin C or vitamin E in aqueous systems. The mechanisms for their antioxidative actions were shown to involve radical scavenging, quenching, and enzyme-inhibiting actions. The preventive actions of proanthcyanidins on diseases relating to reactive oxygen species was examined using animal tests. Proanthocyanidin-rich grape seed extract was showed to have preventive actions on diseases such as atherosclerosis, gastric ulcer, large bowel cancer, cataracts and diabetes. In human intervention trials, grape seed extract was shown to have preventive effects on the increase in lipid peroxides in human plasma after exercise and on muscle fatigue after training. The uses and manufacturing techniques of proanthocyanidin products were subsequently developed. The products were launched as antioxidants in food additives, ingredients in nutritional supplements, and cosmetics.