Targeting helminths: The expanding world of type 2 immune effector mechanisms.

Targeting helminths: The expanding world of type 2 immune effector mechanisms.
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DOI:
10.1084/jem.20221381
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发表时间:
2023-10-02
期刊:
The Journal of experimental medicine
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Maizels和Gause回顾了在皮肤、肺和肠道中蠕虫感染背景下2型免疫的进展,需要协调适应性免疫以集中先天效应细胞和机制,并集中在感染部位。在这篇新的综述中,Rick Maizels和Bill Gause总结了2型免疫反应如何通过新的机制对抗蠕虫寄生虫,协调多种先天和适应性细胞和分子参与者,可以消除感染并修复由此产生的组织损伤。
Maizels and Gause review advances in type 2 immunity in the setting of helminth worm infections, in the skin, lung, and intestinal tract, requiring the orchestration of adaptive immunity to concentrate innate effector cells and mechanisms in scale and focus at the site of infection. In this new review, Rick Maizels and Bill Gause summarize how type 2 immune responses combat helminth parasites through novel mechanisms, coordinating multiple innate and adaptive cell and molecular players that can eliminate infection and repair-resultant tissue damage.
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