Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort
Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort
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DOI：
10.1016/j.drugalcdep.2010.02.020
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发表时间：
2010-08-01
影响因子：
4.2
通讯作者：
Justice, Amy C.
中科院分区：
文献类型：
--
作者：
Green, Traci C.;Kershaw, Trace;Justice, Amy C.
这项研究描述了感染和未感染艾滋病毒的老年人自我报告的吸毒程度和模式，评估了艾滋病毒状况的模式差异，并检查了模式的相关性。数据来自 6351 名 HIV 感染者和未感染者，他们参加了八个地点的匹配队列，即退伍军人老龄化队列研究 (VACS)。利用电子病历和社会人口统计学中的临床变量、药物使用后果以及基线调查中的药物使用频率，我们进行了按 HIV 状态分层的潜在类别分析 (LCA)，并根据临床和社会人口统计学协变量进行了调整。参与者平均年龄 50 岁（范围 22-86 岁），主要是男性 (95%) 和非裔美国人 (64%)。出现了五种不同的模式：非使用者、过去主要大麻使用者、过去多种药物使用者、当前高后果多种药物使用者和当前低后果主要大麻使用者。艾滋病毒状况强烈影响班级成员资格。在未感染艾滋病毒的人群中，非吸毒者最为普遍（36.4%），在艾滋病毒感染者中，目前严重后果的多种药物使用者（25.5%）最为普遍。虽然肥胖问题是那些目前不使用药物的人的特点，但当前使用者的医疗或精神健康障碍的患病率更高。过去和现在的多种药物使用者的多重发病率最高。感染艾滋病毒的参与者比未感染艾滋病毒的参与者更有可能成为目前低后果的主要大麻使用者。在这个样本中，主动吸毒和滥用药物很常见。感染艾滋病毒和未感染艾滋病毒的退伍军人在吸毒程度和模式以及已确定类别的重要特征方面存在差异。研究结果有可能为患有和不患有艾滋病毒的老年吸毒者的筛查和干预工作提供信息。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
This study characterized the extent and patterns of self-reported drug use among aging adults with and without HIV, assessed differences in patterns by HIV status, and examined pattern correlates. Data derived from 6351 HIV-infected and uninfected adults enrolled in an eight-site matched cohort, the Veterans Aging Cohort Study (VACS). Using clinical variables from electronic medical records and socio-demographics, drug use consequences, and frequency of drug use from baseline surveys, we performed latent class analyses (LCA) stratified by HIV status and adjusted for clinical and socio-demographic covariates. Participants were, on average, age 50 (range 22-86), primarily male (95%) and African-American (64%). Five distinct patterns emerged: non-users, past primarily marijuana users, past multidrug users, current high consequence multidrug users, and current low consequence primarily marijuana users. HIV status strongly influenced class membership. Non-users were most prevalent among HIV uninfected (36.4%) and current high consequence multidrug users (25.5%) were most prevalent among HIV-infected. While problems of obesity marked those not currently using drugs, current users experienced higher prevalences of medical or mental health disorders. Multimorbidity was highest among past and current multidrug users. HIV-infected participants were more likely than HIV-uninfected participants to be current low consequence primarily marijuana users. In this sample, active drug use and abuse were common. HIV-infected and uninfected Veterans differed on extent and patterns of drug use and on important characteristics within identified classes. Findings have the potential to inform screening and intervention efforts in aging drug users with and without HIV. (C) 2010 Elsevier Ireland Ltd. All rights reserved.