Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats
Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats
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DOI：
10.1016/j.jep.2005.12.036
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发表时间：
2006-06-30
影响因子：
5.4
通讯作者：
Ohizumi, Yasushi
中科院分区：
文献类型：
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作者：
Ono, Yuka;Hattori, Eri;Ohizumi, Yasushi
莲（Nelumbo nucifera Gaertn.）（睡莲科）在日本和中国已作为家庭疗法用于夏季炎热综合征，并且最近在中国已用于治疗肥胖症。因此，我们对荷叶提取物（NNE）减肥作用的药理机制进行了初步探讨。我们研究了NNE对消化酶活性、脂质代谢和产热的影响，并在用NNE处理5周的高脂饮食诱导的肥胖小鼠中评价了抗肥胖的效果。NNE浓度依赖性抑制C2 C12肌管α-淀粉酶和脂肪酶活性，上调C2 C12肌管脂质代谢和UCP 3 mRNA表达。NNE可防止高脂饮食诱导的肥胖小鼠体重、子宫旁脂肪组织重量和肝脏三酰甘油水平的增加。在运动状态下，NNE组小鼠骨骼肌UCP 3 mRNA的表达有升高的趋势。因此，NNE损害消化，抑制脂质和碳水化合物的吸收，加速脂质代谢和上调能量消耗。因此，NNE有利于抑制肥胖。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The leaf of Nelumbo nucifera Gaertn. (family Nymphaeaceae) has been used for summer heat syndrome as home remedy in Japan and China, and it has recently been used to treat obesity in China. So we investigate the pharmacological mechanism of the anti-obesity effect of Nelumbo nucifera leaves extract (NNE). We examined the effect of NNE on digestive enzyme activity, lipid metabolism and theromogenesis and evaluated the effects of anti-obesity using high-fat diet-induced obesity in mice that were treated with NNE for 5 weeks. NNE caused a concentration-dependent inhibition of the activities of alpha-amylase and lipase, and up-regulated lipid metabolism and expression of UCP3 mRNA in C2C12 myotubes. NNE prevented the increase in body weight, parametrial adipose tissue weight and liver triacylglycerol levels in mice with obesity induced by a high-fat diet. UCP3 mRNA expression in skeletal muscle tended to be higher, when mice were administrated by NNE and were exercised. Therefore, NNE impaired digestion, inhibited absorption of lipids and carbohydrates, accelerated lipid metabolism and up-regulated energy expenditure. Consequently, NNE is beneficial for the suppression of obesity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.