CAN INDUCED MOODS TRIGGER DRUG-RELATED RESPONSES IN OPIATE ABUSE PATIENTS
CAN INDUCED MOODS TRIGGER DRUG-RELATED RESPONSES IN OPIATE ABUSE PATIENTS
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DOI：
10.1016/0740-5472(94)90060-4
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发表时间：
1994-01-01
影响因子：
3.9
通讯作者：
OBRIEN, CP
中科院分区：
文献类型：
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作者：
CHILDRESS, AR;EHRMAN, R;OBRIEN, CP
本研究调查了四种催眠诱导的情绪状态（欣快，抑郁，焦虑和愤怒）的能力，以触发成瘾和其他药物相关的条件反射脱毒阿片类药物滥用患者。催眠诱导的抑郁症产生了显着增加对阿片类药物的渴望。抑郁症也倾向于增加阿片类药物戒断的全球自我评级。其他趋势包括因焦虑而导致的自我渴望增加以及因愤怒而导致的戒断症状增加。这些结果表明，消极的情绪状态，也许在反复尝试自我药疗的背景下，可能成为条件刺激，能够触发渴望和其他与药物相关的条件反应。抑郁症在这一特定患者群体中产生可靠影响的能力可能反映了该样本抑郁症诊断的高终生患病率。这些研究结果的治疗策略的影响进行了讨论。
This study investigated the ability of four hypnotically induced mood states (euphoria, depression, anxiety, and anger) to trigger craving and other drug-related conditioned responses in detoxified opiate abuse patients. Hypnotically induced depression produced significant increases in drug craving for opiates. Depression also tended to increase global self-ratings of opiate withdrawal. Other trends included increases in self-rated craving by induced anxiety and increases in withdrawal symptoms by induced anger. These results suggest that negative mood states, perhaps in the context of repeated attempts at self-medication, may become conditioned stimuli capable of triggering craving and other drug-related conditioned responses. The ability of depression to produce reliable effects in this particular patient group may reflect the high lifetime prevalence of depression diagnoses for this sample. The implications of these findings for therapeutic strategies are discussed.