Epidemiology of breast cancer: retrospective study in the Central African Republic
Epidemiology of breast cancer: retrospective study in the Central African Republic
复制标题
DOI：
10.1186/s12889-016-3863-6
复制
发表时间：
2016-12-07
影响因子：
4.5
通讯作者：
Koffi, Boniface
中科院分区：
文献类型：
--
作者：
Balekouzou, Augustin;Yin, Ping;Koffi, Boniface
背景：乳腺癌在发展中国家被认为是一个主要的公共卫生问题；然而，关于其在中非共和国流行病学的证据非常有限。本研究的目的是调查班吉市乳腺癌的流行病学和组织病理学特征。方法：基于班吉2003 - 2015年病理解剖记录资料进行回顾性研究。设计了一份问卷来收集信息，并使用描述性和推断性统计方法对数据进行分析。结果：患者平均年龄45.83岁（SD = 13.5）。45-54岁年龄组占研究人群的大多数（29.3%）。超过69.5%的妇女是中等经济地位的家庭主妇（56.9%）。只有不到14%的研究人口拥有一定程度的学历，85.6%的人居住在城市。乳腺癌患病率为15.27%。世界人口年龄标准化发病率和死亡率（ASW）分别为11.19/10万和9.97/10万。50-54岁的人受影响最大。左乳腺癌主要是常见的，从首次出现症状到就诊的时间超过48个月。大多数（69%）的样本是乳房肿瘤切除术。乳腺癌最常见的形态为浸润性导管癌（64.9%）。两种常见病理类型均以Scarff Bloom Richardson III级为主，但其所占比例随时间的增加无显著性变化。2 = 7.06, p = 0.54)。不同病理类型乳腺癌的区域淋巴结浸润情况差异有统计学意义（p < 0.05）。2 = 24.6, p = 0.02)。手术和化疗是适当的治疗方法，但仍有84.5%的病例死亡。结论：本研究结果表明，乳腺癌是常见的，主要影响妇女。流行病学趋势或多或少与浸润性导管癌为主的发展中国家相同。然而，大多数被研究的妇女生活在城市地区，并在晚期发病。建立一个适当的框架将有效地促进早期发现和减少人口中这种疾病的发病率。
Background: Breast cancer is recognised as a major public health problem in developing countries; however, there is very limited evidence about its epidemiology in the Central African Republic. The aim of this study was to investigate the epidemiological and histopathological characteristics of breast cancer in Bangui.Methods: This is a retrospective study based on the data collected from pathological anatomy records from 2003 to 2015 in Bangui. A questionnaire was designed to collect information and data was analysed using descriptive and inferential statistical methods.Results: The mean age was 45.83 (SD = 13.5) years. The age group of 45-54 years represented the majority of the study population (29.3%). Over 69.5% of the women were housewives with a moderate economic status (56.9%). Less than 14% of the study population had a level of academic degree and 85.6% lived in cities. The breast cancer prevalence was 15.27%. The age-standardized incidence and death by world population (ASW) were 11.19/100,000 and 9.97/100,000 respectively. 50-54 years were most affected. Left breast cancer is mainly common and the time between first symptoms and consultation is more than 48 months. Most (69%) of the samples analysed were lumpectomy. The most common morphology of breast cancer was invasive ductal carcinoma (64.9%). Scarff Bloom Richardson III was the main grade in both common pathological types, but their proportion showed no significant increase along with time (.2 = 7.06, p = 0.54). Invasion of regional lymph node differed significantly among the pathological type of breast cancer (.2 = 24.6, p = 0.02). Surgery and chemotherapy were appropriate treatment yet 84.5% of the cases died.Conclusion: The findings of this study showed that breast cancer is common and mostly affected women. Epidemiological trends are more or less common to those of developing countries with a predominance of invasive ductal carcinoma. However, most of the women studied live in an urban area and developed the disease in advanced stage. The establishment of an appropriate framework will effectively contribute to promoting the early detection and reducing the incidence of this disease in the population.