Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions
Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions
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DOI：
10.1016/j.placenta.2014.05.006
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发表时间：
2014-08-01
期刊：
影响因子：
3.8
通讯作者：
Wang, Weiye
中科院分区：
文献类型：
--
作者：
Huang, Lisu;Liu, Jihong;Wang, Weiye
孕前肥胖与母亲和后代的发病率和死亡率增加有关。本研究的目的是评估孕妇孕前体重对胎盘病理病变的影响。方法：本研究使用的数据来自美国围产期合作项目，这是一项大型前瞻性队列研究。它包括54390名在1959年至1966年期间生育一胎的妇女。超过84%的女性进行了详细的胎盘病理检查和人体测量测量。采用Logistic回归模型检验孕妇孕前体重指数（BMI）与胎盘病理病变之间的相关性，并对潜在混杂因素进行校正。采用样条平滑法描述孕前体重指数与胎盘出生体重比的关系。结果：孕前肥胖妇女（BMI >= 30 kg/m(2)）的母源性血管病变、母源性绒毛病变、胎儿中性粒细胞浸润、胎膜胎便率均高于正常体重妇女（18.5）
Introduction: Prepregnancy obesity is associated with increased morbidity and mortality for mother and offspring. The objective of our study is to estimate the effect of maternal prepregnancy weight on placental pathological lesions..Methods: Data used for this study were from the U.S. Collaborative Perinatal Project, a large prospective cohort study. It consisted of 54390 women giving a singleton birth from 1959 to 1966. More than 84% of women had both detailed placental pathological examinations and anthropometric measurements. Logistic regression models were used to test the associations between maternal prepregnancy body mass index (BMI) and placental pathological lesions adjusting for potential confounders. Spline smoothing was applied to describe the relation of prepregnancy BMI and placenta weight-to-birthweight ratio.Results: The prepregnancy obese women (BMI >= 30 kg/m(2)) showed a higher rate of maternal origin vascular lesions, maternal origin villous lesions, fetal neutrophilic infiltration, and meconium of fetal membrane compared with the normal-weight women (18.5