Association between inflammatory potential of diet and risk of depression in middle-aged women: the Australian Longitudinal Study on Women's Health
Association between inflammatory potential of diet and risk of depression in middle-aged women: the Australian Longitudinal Study on Women's Health
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DOI：
10.1017/s0007114516002853
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发表时间：
2016-09-01
影响因子：
3.6
通讯作者：
Mishra, Gita D.
中科院分区：
文献类型：
--
作者：
Shivappa, Nitin;Schoenaker, Danielle A. J. M.;Mishra, Gita D.
饮食因素和炎症标志物已被证明在抑郁症的发展中发挥作用。然而，很少有研究探讨饮食的炎症潜力与抑郁症风险之间的关系。在这项研究中，我们研究了饮食炎症指数（DII），这是专门用来衡量饮食的炎症潜力，和抑郁症的风险在澳大利亚妇女健康纵向研究的中年队列之间的关联。共有6438名基线平均年龄为52.0（sd 1.4）岁的女性在12年（2001-2013）的5次调查中接受了随访。抑郁症被定义为在流行病学研究中心抑郁-10量表上得分>= 10。DII评分是一种基于文献的、基于人群的饮食指数，已针对几种炎症标志物进行了验证，其计算基于使用经验证的FFQ评估的饮食摄入量。根据DII评分，采用广义估计方程估计抑郁症的相对危险度（RR）。模型调整了能量摄入，完成的最高教育，婚姻状况，更年期状态和症状，个人疾病或伤害，吸烟状况，体力活动，BMI和抑郁症诊断或治疗。总共有1156名妇女（18%）在9年的时间里在CESD量表上得分>= 10。最抗炎饮食的女性与最促炎饮食的女性相比，患抑郁症的风险降低约20%（RRDII四分位数（1 nu. 4）：w 0.81; 95% CI 0.69，0.96; P趋势=0.03）。这些结果表明，抗炎饮食与澳大利亚中年妇女患抑郁症的风险较低有关。
Dietary factors and inflammation markers have been shown to play a role in the development of depression. However, there are very few studies that have explored the association between inflammatory potential of diet and risk of depression. In this study, we examined the association between the dietary inflammatory index (DII), which was developed specifically to measure the inflammatory potential of diet, and risk of depression in the middle-aged cohort of the Australian Longitudinal Study on Women's Health. A total of 6438 women with a mean age of 52.0 (sd 1.4) years at baseline were followed-up at five surveys over 12 years (2001-2013). Depression was defined as a score of >= 10 on the Center for Epidemiologic Studies Depression-10 scale. The DII score, a literature-derived, population-based dietary index that has been validated against several inflammatory markers, was computed on the basis of dietary intake assessed using a validated FFQ. Generalised estimating equations were used to estimate relative risk (RR) of depression according to DII score. Models were adjusted for energy intake, highest education completed, marital status, menopause status and symptoms, personal illness or injury, smoking status, physical activity, BMI and depression diagnosis or treatment. In total, 1156 women (18 %) had scores >= 10 on the CESD scale over the course of 9 years. Women with the most anti-inflammatory diet had an approximately 20 % lower risk of developing depression compared with women with the most pro-inflammatory diet (RRDII quartile (1 nu. 4):w 0.81; 95 % CI 0.69, 0.96; P-trend=0.03). These results suggest that an anti-inflammatory diet is associated with lower risk of depression in middle-aged Australian women.