Dural arachnoid granulations and "giant" arachnoid granulations
Dural arachnoid granulations and "giant" arachnoid granulations
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DOI：
10.1007/s00276-008-0345-2
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发表时间：
2008-07-01
影响因子：
1.4
通讯作者：
Soffer, Dov
中科院分区：
文献类型：
--
作者：
Haybaeck, Johannes;Silye, Rene;Soffer, Dov
虽然300多年前Antonio Pacchioni就已经描述了蛛网膜颗粒（AGs），但有两个问题引起了特别的关注：第一，所谓的巨型AGs（GAGs）的放射学特征和鉴别诊断，第二，它们与各种疾病过程的可能联系。为了评价GAG的频率、大小和正态分布，对硬脑膜窦进行了解剖学研究。它涉及2002年8月至2005年2月期间进行的所有尸检，包括651例病例：306例女性和345例男性，年龄13-99岁（平均69岁）。在24例病例中确定了肉眼可见的GAG：7例女性和17例男性，年龄45-92岁（平均69岁）。这是最大的基于人群的GAG解剖学研究。它表明，GAG通常是一种罕见的发现（3.68%），在成年人群中相当常见，特别是在老年人（年龄> 65岁）中，并且它们可以达到显著的尺寸（直径高达2.5 cm或更大）。在硬脑膜内病变的影像学鉴别诊断中，尤其是发生在老年人横窦内的硬脑膜内病变，应考虑到巨大AG。
Although arachnoid granulations (AGs) were already described by Antonio Pacchioni more than 300 years ago, two issues draw particular attention: first, the radiological features and differential diagnosis of the so-called giant AGs (GAGs) and second, their possible association with various disease processes. In order to evaluate the frequency, size and normal distribution of GAGs, an anatomical study of the dural sinuses was carried out. It involved all the autopsies performed during the period August 2002-February 2005 and included 651 cases: 306 females and 345 males, aged 13-99 years (mean 69 years). Grossly visible GAGs were identified in 24 cases: 7 females and 17 males, aged 45-92 years (mean 69 years). This is the largest population-based anatomical study on GAGs. It shows that GAGs, in general a rare finding (3.68%), are rather common in the adult population, especially in the elderly (aged > 65 years) and that they can reach remarkable size (up to 2.5 cm and more in diameter). Giant AGs should be considered in the radiological differential diagnosis of intradural lesions, particularly those occurring in the transverse sinus of the elderly.