Elastic 3D-Printed Hybrid Polymeric Scaffold Improves Cardiac Remodeling after Myocardial Infarction
Elastic 3D-Printed Hybrid Polymeric Scaffold Improves Cardiac Remodeling after Myocardial Infarction
复制标题
弹性 3D 打印混合聚合物支架可改善心肌梗塞后的心脏重塑
DOI：
10.1002/adhm.201900065
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发表时间：
2019
影响因子：
10
通讯作者：
Zhao Qiang
中科院分区：
文献类型：
--
作者：
Yang Yang;Lei Dong;Huang Shixing;Yang Qi;Song Benyan;Guo Yifan;Shen Ao;Yuan Zhize;Li Sen;Qing Feng-Ling;Ye Xiaofeng;You Zhengwei;Zhao Qiang
Myocardial remodeling, including ventricular dilation and wall thinning, is an important pathological process caused by myocardial infarction (MI). To intervene in this pathological process, a new type of cardiac scaffold composed of a thermoset (poly‐[glycerol sebacate], PGS) and a thermoplastic (poly‐[ε‐caprolactone], PCL) is directly printed by employing fused deposition modeling 3D‐printing technology. The PGS‐PCL scaffold possesses stacked construction with regular crisscrossed filaments and interconnected micropores and exhibits superior mechanical properties. In vitro studies demonstrate favorable biodegradability and biocompatibility of the PGS‐PCL scaffold. When implanted onto the infarcted myocardium, this scaffold improves and preserves heart function. Furthermore, the scaffold improves several vital aspects of myocardial remodeling. On the morphological level, the scaffold reduces ventricular wall thinning and attenuated infarct size, and on the cellular level, it enhances vascular density and increases M2 macrophage infiltration, which might further contribute to the mitigated myocardial apoptosis rate. Moreover, the flexible PGS‐PCL scaffold can be tailored to any desired shape, showing promise for annular‐shaped restraint device application and meeting the demands for minimal invasive operation. Overall, this study demonstrates the therapeutic effects and versatile applications of a novel 3D‐printed, biodegradable and biocompatible cardiac scaffold, which represents a promising strategy for improving myocardial remodeling after MI.
