Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass
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DOI：
10.1016/j.cmet.2007.06.002
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发表时间：
2007-07-01
期刊：
影响因子：
29
通讯作者：
Kahn, Barbara B.
中科院分区：
文献类型：
--
作者：
Kloeting, Nora;Graham, Timothy E.;Kahn, Barbara B.
腹内脂肪与胰岛素抵抗和心血管风险相关。由脂肪和肝细胞分泌的血清视黄醇结合蛋白（RBP 4）水平在肥胖和2型糖尿病（T2 D）中增加。在这里，我们报告说，在196名受试者中，RBP 4优先在内脏（维斯）脂肪而不是皮下（SC）脂肪中表达。维斯脂肪RBP 4 mRNA在维斯和SC肥胖受试者中分别比瘦受试者增加了60倍和12倍，并且与血糖正常受试者相比，葡萄糖耐量受损/T2 D受试者增加了2倍。在肥胖受试者中，血清RBP 4增加2至3倍，血清甲状腺素运载蛋白，稳定循环中的RBP 4，增加35%。血清RBP 4与脂肪RBP 4 mRNA和腹内脂肪量呈正相关，与胰岛素敏感性呈负相关，与年龄、性别和体重指数无关。RBP 4 mRNA与维斯脂肪中的GLUT 4 mRNA呈负相关，而与两个贮库中的脂肪细胞大小呈正相关。因此，RBP 4水平与维斯肥胖有关，而维斯脂肪可能是胰岛素抵抗状态下RBP 4的主要来源。
Intra-abdominal fat is associated with insulin resistance and cardiovascular risk. Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D). Here we report that, in 196 subjects, RBP4 is preferentially expressed in visceral (Vis) versus subcutaneous (SC) fat. Vis fat RBP4 mRNA was increased similar to 60-fold and 12-fold in Vis and SC obese subjects respectively versus lean subjects, and similar to 2-fold with impaired glucose tolerance/T2D subjects versus normoglycemic subjects. In obese subjects, serum RBP4 was increased 2- to 3-fold, and serum transthyretin, which stabilizes RBP4 in the circulation, was increased 35%. Serum RBP4 correlated positively with adipose RBP4 mRNA and intra-abdominal fat mass and inversely with insulin sensitivity, independently of age, gender, and body mass index. RBP4 mRNA correlated inversely with GLUT4 mRNA in Vis fat and positively with adipocyte size in both depots. RBP4 levels are therefore linked to Vis adiposity, and Vis fat may be a major source of RBP4 in insulin-resistant states.