Role of Wnt signaling pathway in joint development and cartilage degeneration.
Role of Wnt signaling pathway in joint development and cartilage degeneration.
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Wnt信号通路在关节发育和软骨退变中的作用。
DOI：
10.3389/fcell.2023.1181619
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发表时间：
2023
影响因子：
5.5
通讯作者：
Feng, Chen
中科院分区：
文献类型：
--
作者：
Li, Xinyan;Han, Yuanyuan;Li, Guimiao;Zhang, Yingze;Wang, Juan;Feng, Chen
骨关节炎（OA）是一种普遍的肌肉骨骼疾病，影响全球约5亿人。不幸的是，目前还没有有效的治疗方法来阻止或延缓关节疾病的退行性进展。Wnt信号通路在调节关节软骨的生长、发育和体内平衡中起着重要作用。这篇综述旨在总结Wnt通路在胚胎阶段关节发育和成年期软骨维持中的作用。特别地，我们关注异常机械负荷和炎症作为OA进展的主要参与者。过大的机械负荷激活软骨细胞中的Wnt通路，导致软骨细胞凋亡、基质破坏等骨关节炎相关改变。此外，我们还讨论了新兴的Wnt相关调节剂，并概述了针对Wnt信号的OA新兴治疗方法。最终，本综述为发现针对Wnt信号通路的新药或基因疗法用于骨关节炎和其他退行性关节疾病的诊断和治疗提供了有价值的见解。
Osteoarthritis (OA) is a prevalent musculoskeletal disease that affects approximately 500 million people worldwide. Unfortunately, there is currently no effective treatment available to stop or delay the degenerative progression of joint disease. Wnt signaling pathways play fundamental roles in the regulation of growth, development, and homeostasis of articular cartilage. This review aims to summarize the role of Wnt pathways in joint development during embryonic stages and in cartilage maintenance throughout adult life. Specifically, we focus on aberrant mechanical loading and inflammation as major players in OA progression. Excessive mechanical load activates Wnt pathway in chondrocytes, resulting in chondrocyte apoptosis, matrix destruction and other osteoarthritis-related changes. Additionally, we discuss emerging Wnt-related modulators and present an overview of emerging treatments of OA targeting Wnt signaling. Ultimately, this review provides valuable insights towards discovering new drugs or gene therapies targeting Wnt signaling pathway for diagnosing and treating osteoarthritis and other degenerative joint diseases.
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