Validation of a method for noninvasive measurement of central arterial pressure.
Validation of a method for noninvasive measurement of central arterial pressure.
复制标题
验证中心动脉压无创测量方法。
DOI：
10.1161/01.hyp.21.1.74
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Kass,DA
中科院分区：
文献类型：
--
作者：
Sharir,T;Marmor,A;Ting,CT;Chen,JW;Liu,CP;Chang,MS;Yin,FC;Kass,DA
本研究的目的是验证一种新改进的无创方法，用于校准测量人类中央动脉压力波的上升部分。在计算机控制的上臂袖带放气过程中，通过测量心电图 R 波与肱动脉血流开始（通过多普勒）之间的时间延迟来生成无创压力波形。随着袖带压力下降（在舒张压或舒张压以下变得接近恒定），该延迟会缩短，因此压力与时间延迟的关系图会产生动脉波形的上升部分。这些波形与 57 名成年患者（其中 31 名通过流体压力计[A 组]，26 名通过导管尖端微压计[B 组]）在常规心导管插入术期间同步有创升主动脉压进行了比较。患者年龄从26岁到77岁不等。 A 组 80% 的患者和 B 组 40% 的患者患有冠状动脉疾病。两组的无创收缩压和舒张压与有创值非常相似（Pni = 0.98 x Pi，r = 0.99，p < 0.0001）。两组波形之间的瞬时压力差也相似，平均在 4.5 至 5.5 mm Hg 之间。在静脉注射硝酸甘油 (n = 5) 和等长手柄 (n = 8) 之前和之后还获得了微压计和无创压力数据，并显示出良好的一致性。这些压力的潜在应用是估计最大心室功率以评估收缩功能。这是使用四名患者在各种条件下（运动、起搏等）的有创压力容积数据进行测试的。（摘要截断为 250 字）
The goal of this study was to validate a newly improved noninvasive method for calibrated measurement of the ascending portion of the central arterial pressure wave in humans. Noninvasive pressure waveforms were generated by measuring the time delay between the R wave of the electrocardiogram and onset of brachial artery flow (by Doppler) during computer-controlled upper arm cuff deflation. This delay shortens with falling cuff pressure (becoming near constant at and below diastolic pressure), so that a plot of pressure versus time delay yields the ascending portion of the arterial waveform. These waveforms were compared with simultaneous invasive ascending aortic pressures in 57 adult patients (31 by fluid manometer [group A] and 26 by catheter-tipped micromanometer [group B]) during routine cardiac catheterization. Patient age ranged from 26 to 77 years. Eighty percent of group A patients and 40% of group B had coronary artery disease. Noninvasive systolic and diastolic pressures were very similar to invasive values in both groups (Pni = 0.98 x Pi, r = 0.99, p < 0.0001). Instantaneous pressure differences between waveforms were also similar in both groups, averaging between 4.5 and 5.5 mm Hg. Micromanometer and noninvasive pressure data were also obtained before and after intravenous nitroglycerin (n = 5) and isometric handgrip (n = 8) and demonstrated good agreement. A potential application of these pressures is for estimating maximal ventricular power to assess systolic function. This was tested using invasive pressure-volume data from four patients under a variety of conditions (exercise, pacing, etc.).(ABSTRACT TRUNCATED AT 250 WORDS)