Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related Diseases.
Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related Diseases.
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DOI：
10.3390/v7122952
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发表时间：
2015-12-09
期刊：
影响因子：
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通讯作者：
Péloponèse JM
中科院分区：
文献类型：
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作者：
Mesnard JM;Barbeau B;Césaire R;Péloponèse JM
自人类 T 细胞白血病病毒 1 型 (HTLV-1) 被描述为第一种导致人类癌症成人 T 细胞白血病 (ATL) 的逆转录病毒以来，已经过去了三十多年，但 HTLV-1 发病机制背后的精确机制仍然难以捉摸。二十多年来，HTLV-1 的转化能力一直与病毒反式激活因子相关。十三年前，我们首次报道了 HTLV-1 的负链编码基本 Zip 因子 (HBZ)，从那时起，多个团队强调了这种反义病毒蛋白对于维持慢性感染和受感染细胞增殖的重要性。最近，我们和其他人已经证明 HBZ 具有在体外和体内转化细胞的潜力。在这篇综述中，我们重点关注 HBZ 在慢性和细胞转化中的功能理解的最新进展。我们将讨论 HTLV-1 研究范式转变对治疗 HTLV-1 相关人类疾病的新治疗方法的影响。
More than thirty years have passed since human T-cell leukemia virus type 1 (HTLV-1) was described as the first retrovirus to be the causative agent of a human cancer, adult T-cell leukemia (ATL), but the precise mechanism behind HTLV-1 pathogenesis still remains elusive. For more than two decades, the transforming ability of HTLV-1 has been exclusively associated to the viral transactivator Tax. Thirteen year ago, we first reported that the minus strand of HTLV-1 encoded for a basic Zip factor factor (HBZ), and since then several teams have underscored the importance of this antisense viral protein for the maintenance of a chronic infection and the proliferation of infected cells. More recently, we as well as others have demonstrated that HBZ has the potential to transform cells both in vitro and in vivo. In this review, we focus on the latest progress in our understanding of HBZ functions in chronicity and cellular transformation. We will discuss the involvement of this paradigm shift of HTLV-1 research on new therapeutic approaches to treat HTLV-1-related human diseases.