Genetic and epigenetic changes in nasopharyngeal carcinoma
Genetic and epigenetic changes in nasopharyngeal carcinoma
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DOI：
10.1016/s1044579x02000883
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发表时间：
2002-12-01
影响因子：
14.5
通讯作者：
Huang, DP
中科院分区：
文献类型：
--
作者：
Lo, KW;Huang, DP
鼻咽癌是一种具有显著种族和地理分布的恶性肿瘤。这种EBV相关癌症的发展可能涉及遗传和环境因素背景下累积的遗传和表观遗传变化。全基因组研究揭示了涉及特定癌基因和肿瘤抑制基因的多种染色体异常。Ras相关结构域家族1A(RASSF1A)、p16/INK4a、p14/ARF等基因的改变提示鼻咽癌细胞内多条细胞通路失调。对癌前病变的研究揭示了早期的遗传变化和EBV潜伏感染在该癌发展中的关键作用。在已有研究的基础上，提出了鼻咽癌的致病模型。
Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable racial and geographic distribution. The development of this EBV-associated cancer likely involves cumulative genetic and epigenetic changes in a background of predisposed genetic and environmental factors. Genome-wide studies have unravelled multiple chromosomal abnormalities with involvement of specific oncogenes and tumour suppressor genes. Alterations of genes such as Ras association domain family 1A (RASSF1A), p16/INK4A, p14/ARF suggest that multiple cellular pathways were dysregulated in the NPC cells. Studies on the precancerous lesions revealed early genetic changes and a critical role of EBV latent infection in the development of this cancer. Based on the existing findings, a pathogenetic model for NPC is proposed.