The effect of arylazido aminopropionyl ATP on atropine resistant contractions of the cat urinary bladder.
The effect of arylazido aminopropionyl ATP on atropine resistant contractions of the cat urinary bladder.
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芳基叠氮氨基丙酰 ATP 对猫膀胱阿托品耐药收缩的影响。
DOI：
10.1016/0024-3205(83)90374-0
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发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
TheobaldJr,RJ
中科院分区：
文献类型：
--
作者：
TheobaldJr,RJ
这项工作旨在研究神经源性的、阿托品抵抗的猫膀胱收缩。刺激盆腔神经(PNS)，注射乙酰胆碱(Ach)和嘌呤类化合物，诱发膀胱收缩。结果表明，阿托品(2 mg/kg)抑制三七总皂苷和乙酰胆碱诱发的收缩的持续部分(2相)，而对三七总皂苷诱发的收缩的起始部分(1相)或嘌呤诱发的收缩无影响。ATP拮抗剂芳拉齐多氨基丙酰三磷酸腺苷(ANAPP3)抑制PNS收缩和嘌呤引起的收缩的第一时相。这些结果表明，ATP至少是猫膀胱阿托品抵抗收缩的部分原因。
This work was designed to study neurogenic, atropine resistant contractions of the cat urinary bladder. Urinary bladder contractions were induced by pelvic nerve stimulation (PNS) and the administration of acetylcholine (Ach) and purine compounds. The results show that atropine (2 mg/kg) depresses the maintained portion (phase 2) of PNS-induced contractions and Ach-induced contractions while having no effect on the initial portion (phase 1) of the PNS-induced contractions or those contractions induced by the purines. Arylazido aminopropionyl ATP (ANAPP3), an ATP antagonist, depressed phase 1 of the PNS contraction and the purine induced contractions. These results suggest that ATP is responsible for at least part of the atropine-resistant contractions of the cat urinary bladder.