Secondary transport as an efficient membrane transport mechanism for plant secondary metabolites
Secondary transport as an efficient membrane transport mechanism for plant secondary metabolites
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DOI：
10.1007/s11101-007-9079-8
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发表时间：
2008-10
影响因子：
7.7
通讯作者：
K. Yazaki;A. Sugiyama;M. Morita;N. Shitan
中科院分区：
文献类型：
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作者：
K. Yazaki;A. Sugiyama;M. Morita;N. Shitan
植物产生大量的次生代谢产物，如生物碱、萜类化合物和酚类化合物。植物次生代谢产物具有多种功能，包括保护植物免受病原体和紫外线的侵害，并已利用其多种生物活性用作人类的天然药物。这些天然化合物中的许多积累在特定的隔室中，例如液泡，有些甚至通过长距离运输从源细胞转移到库器官。初级和次级转运蛋白都参与了这种区室化和转运，许多转运蛋白基因，特别是拟南芥中由56个成员组成的多药和毒素挤出型转运蛋白家族的基因，已被鉴定为负责次级代谢物的膜转运。更好地了解这些转运蛋白以及次生代谢产物的生物合成基因将是重要的代谢工程，旨在提高生产的商业价值的次生代谢产物在植物细胞中。
Plants produce a large number of secondary metabolites, such as alkaloids, terpenoids, and phenolic compounds. Secondary metabolites have various functions including protection against pathogens and UV light in plants, and have been used as natural medicines for humans utilizing their diverse biological activities. Many of these natural compounds are accumulated in a particular compartment such as vacuoles, and some are even translocated from source cells to sink organs via long distance transport. Both primary and secondary transporters are involved in such compartmentation and translocation, and many transporter genes, especially genes belonging to the multidrug and toxin extrusion type transporter family, which consists of 56 members in Arabidopsis, have been identified as responsible for the membrane transport of secondary metabolites. Better understandings of these transporters as well as the biosynthetic genes of secondary metabolites will be important for metabolic engineering aiming to increase the production of commercially valuable secondary metabolites in plant cells.