Overlapping corticostriatal projections from the rodent vibrissal representations in primary and secondary somatosensory cortex
Overlapping corticostriatal projections from the rodent vibrissal representations in primary and secondary somatosensory cortex
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DOI：
10.1002/1096-9861(20001009)426:1
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发表时间：
2000-10-09
影响因子：
2.5
通讯作者：
Hoover, JE
中科院分区：
文献类型：
--
作者：
Alloway, KD;Mutic, JJ;Hoover, JE
为了确定是否新纹状体接收重叠的预测从两个躯体感觉皮质区，顺行示踪剂生物素化葡聚糖胺（BDA）和荧光红宝石（FR）被注入到晶须表示的初级（SI）和次级（SII）躯体感觉皮质。重建标记的终端和他们的珠状静脉曲张在新纹状体和丘脑进行了定量分析，比较重叠的投射到两个皮层下结构的程度。皮质纹状体的预测从两个躯体感觉区的焦点网站表现出大量的分歧内的背外侧新纹状体。大多数标记的终端集中在密集的树枝状占据板状区域沿着背外侧边缘的新纹状体。示踪剂注射在两个皮质区也产生了密集的顺行和逆行标记在丘脑，特别是在腹侧基底复合体（VB）和后（POm）核的内侧部分。由于这些丘脑区域是地形组织的，并且与SI和SII中的相应表示具有相互联系，因此丘脑中标记的重叠量用于指示SI和SII注射部位的躯体位置对应程度。我们发现新纹状体的重叠投射的比例与丘脑中观察到的重叠量适度相关。这一结果强烈表明，在背外侧新纹状体的特定网站接收会聚投影从相应的躯体位置表示在SI和SII，但也表明，一些corticostriatal分歧可能反映新纹状体整合的体感信息从noncorresponding表示在SI和SII。(C)2000 Wiley-Liss，Inc.
To determine whether the neostriatum receives overlapping projections from two somatosensory cortical areas, the anterograde tracers biotinylated dextran amine (BDA) and fluoro-ruby (FR) were injected into the whisker representations of primary (SI) and secondary (SII) somatosensory cortex. Reconstructions of labeled terminals and their beaded varicosities in the neostriatum and thalamus were analyzed quantitatively to compare the extent of overlapping projections to both subcortical structures. Corticostriatal projections from focal sites in both somatosensory areas exhibited substantial amounts of divergence within the dorsolateral neostriatum. Most of the labeled terminals were concentrated in densely packed arborizations that occupied lamellar-shaped regions along the dorsolateral edge of the neostriatum. Tracer injections in both cortical areas also produced dense anterograde and retrograde labeling in the thalamus, especially in the ventrobasal complex (VB) and in the medial part of the posterior (POm) nucleus. Because these thalamic regions are topographically organized and have reciprocal connections with corresponding representations in both SI and SII, the amount of labeled overlap in the thalamus was used to indicate the degree of somatotopic correspondence at the SI and SII injection sites. We found that the proportion of overlapping projections to the neostriatum was moderately correlated with the amount of overlap observed in the thalamus. This result strongly indicates that specific sites in the dorsolateral neostriatum receive convergent projections from corresponding somatotopic representations in SI and SII, but also suggests that some of the corticostriatal divergence may reflect neostriatal integration of somatosensory information from noncorresponding representations in SI and SII. (C) 2000 Wiley-Liss, Inc.